Introduction to Medicinal Chemistry

ISBN-10: 0199234477

ISBN-13: 9780199234479

Edition: 4th 2009

List price: $67.99
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The average person in the UK will take more than 14,000 pills over the course of their life, yet few people consider the long road of development that has made that drug work without being toxic. An Introduction to Medicinal Chemistry presents the field in an engaging style that is veryaccessible to students.Medicinal chemistry is a fast-moving field whose continuous new developments have far-reaching implications for world health. As such, this text presents a complete course in medicinal chemistry, from first principles of drug action, to design and development, to specific drugs from HIV inhibitorsto painkillers.The book builds on the history of drug development, but does not assume much background knowledge. The focus is on building upon the understandings of the molecular function of drugs, and from there, taking a broad overview of the topical issues and most frequently used techniques.An Introduction to Medicinal Chemistry remains a leading text for the growing number of medicinal chemistry courses internationally, especially as modules in medical chemistry become a more popular option on chemistry courses. With enhanced attention to the pedagogical details such as key pointsand boxes, as well as having specific case studies highlighted in distinct sections, Patrick's new edition enables a full understanding of the subject and a clear idea of where the field is heading.Online Resource CentreThe Online Resource Centre features:For registered adoptors of the book:DT Answers to end-of-chapter questionsDT Figures from the bookDT Power Point slidesDT Test Bank questionsFor students:DT Hyperlinked bibliographyDT Six-monthly updates to textDT 3D Rotatable structures
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Book details

List price: $67.99
Edition: 4th
Copyright year: 2009
Publisher: Oxford University Press, Incorporated
Publication date: 3/25/2009
Binding: Paperback
Pages: 752
Size: 7.75" wide x 10.25" long x 1.75" tall
Weight: 1.166
Language: English

Drugs and drug targets: an overview
Drug targets: Structure and Function
Protein structure and function
Enzymes: structure and function
Receptors: structure and function
Receptors and signal transduction
Nucleic acids - structure and function
Pharmacodynamics and pharmacokinetics
Enzymes as drug targets
Receptors as drug targets
Nucleic acids as drug targets
Other drug targets
Pharmacokinetics and related topics
Drug discovery, design, and development
Drug discovery: finding a lead
Drug design: optimizing target interactions
Drug design: optimizing access to the target
Drug development
The design of ACE inhibitors
Artemisinin and related antimalarial drugs
The design of oxamniquine
Tools of the trade
Combinatorial synthesis
Computers in medicinal chemistry
Quantitative structure-activity relationships (QSAR)
De novo design of a thymidylate synthase inhibitor
Design of a serotonin antagonist
Selected topics in medicinal chemistry
Antibacterial agents
Antiviral agents
Anticancer agents
The peripheral nervous system: cholinergics, anticholinergics, and anticholinesterases
The andrenergic nervous system
The opium analgesics
Anti-ulcer agents
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