Livia Candelise, Cochrane Neurological Network, Dipartimento di Scienze Neurologiche, Ospedale Maggiore Policlinico, Universita' degli Studi di Milano, Milan, ItalyRichard Hughes, Department of Clinical Neurosciences, King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals, London, UKAlessandro Liberati. Department of Hematology and Oncology, University of Modena and Reggio Emilia, Azienda Ospedaliera Policlinico, Ferrara, ItalyBernard Uitdehaag, Department of Neurology and Department of Clinical Epidemiology and Biostatistics, VU Medical Centre, Amsterdam, The NetherlandsCharles Warlow, Department of Clinical Neurosciences, Western General Hospital,… Edinburgh, UK