Gordon Guyatt, MD, MSc Departments of Clinical Epidemiology and Biostatistics and Medicine Faculty of Health Sciences McMaster University Hamilton, OntarioDrummond Rennie, MD JAMA, Chicago, IL Philip R. Lee Institute for Health Policy Studies University of California, San Francisco San Francisco, CAMaureen O. Meade, MD, FRCPC, MSc Departments of Medicine and Clinical Epidemiology and Biostatistics Faculty of Health Sciences McMaster University Hamilton, OntarioDeborah J. Cook, MD, MSc Department of Medicine and Clinical Epidemiology and Biostatistics Faculty of Health Sciences McMaster University Hamilton, Ontario