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Medical Literature A Manual for Evidence-Based Clinical Practice

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ISBN-10: 007159034X

ISBN-13: 9780071590341

Edition: 2nd 2008

Authors: Gordon Guyatt, Drummond Rennie, Deborah Cook, Maureen Meade, Maureen Meade

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The #1 guide to the principles and clinical applications of evidence-based medicine has just gotten better! No other resource helps you to put key evidence-based medicine protocols into daily clinical practice better than "Users' Guides to the Medical Literature," An instant classic in its first edition, this detailed, yet highly readable reference demystifies the statistical, analytical, and clinical principles of evidence-based medicine, giving you a hands-on, practical resource that no other text can match. Here, you'll learn how to distinguish solid medical evidence from poor medical evidence, devise the best search strategies for each clinical question, critically appraise the medical…    
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Book details

Edition: 2nd
Copyright year: 2008
Publisher: McGraw-Hill Professional Publishing
Publication date: 5/21/2008
Binding: Paperback
Pages: 860
Size: 6.00" wide x 9.00" long x 1.50" tall
Weight: 2.244
Language: English

Gordon Guyatt, MD, Deputy Editor, JAMA; Professor of Medicine, McMaster University, Hamilton, Ontario, Canada. Drummond Rennie, MD, Professor of Medicine, UCSF School of Medicine, San Francisco, CA Maureen Meade, MD, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Deborah Cook, MD, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

The Foundations
How to Use the Medical Literature-and This Book-to Improve Your Patient Care
The Philosophy of Evidence-Based Medicine
What Is the Question?
Finding the Evidence
Why Study Results Mislead: Bias and Random Error
Therapy (Randomized Trials)
Does Treatment Lower Risk? Understanding the Results
Confidence Intervals
Advanced Topics in the Validity of Therapy Trials
An Illustration of Bias and Random Error
Surprising Results of Randomized Trials
Randomized Trials Stopped Early for Benefit
The Principle of Intention to Treat
N-of-1 Randomized Controlled Trials
Clinical Decision Support Systems
Advanced Topics in the Results of Therapy Trials
Hypothesis Testing
Understanding the Results: More About Odds Ratios
What Determines the Width of the Confidence Interval?
Composite Endpoints
Measuring Patients' Experience
Advanced Topics in Applying the Results of Therapy Trials
Applying Results to Individual Patients
Example Numbers Needed to Treat
Dealing With Misleading Presentations of Clinical Trial Results
Surrogate Outcomes
Qualitative Research
Harm (Observational Studies)
Harm (Observational Studies)
Advanced Topics in Harm: Correlation and Regression
The Process of Diagnosis
Differential Diagnosis
Diagnostic Tests
Advanced Topics in Diagnosis
Spectrum Bias
Examples of Likelihood Ratios
Measuring Agreement Beyond Chance
Clinical Prediction Rules
Summarizing the Evidence
Summarizing the Evidence
Advanced Topics in Systematic Reviews
Reporting Bias
Fixed-Effects and Random-Effects Models
Making Sense of Variability in Study Results
When to Believe a Subgroup Analysis
Moving From Evidence to Action
How to Use a Patient Management Recommendation
Advanced Topics in Moving From Evidence to Action
Economic Analysis
Decision Making and the Patient
Moving From Evidence to Action: Recommendations About Screening
Grading Recommendations
Drug Class Effects
Parallel but Separate Goals: Evidence-Based Practitioners and Evidence-Based Care
Changing Behavior to Apply Best Evidence in Practice
Teachers' Guides to the Users' Guides