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Inhibition of Angiogenesis by Potential Chemopreventive Agents

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ISBN-10: 3639036301

ISBN-13: 9783639036305

Edition: 2008

Authors: Elisabeth Klenke

List price: $76.00
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Description:

A new human in vitro anti-angiogenesis assay was established and applied to identify novel angiopreventive agents. Subsequently, two chemopreventive compounds, xanthohumol (XN) from Humulus lupulus L. (hop) and sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables (Brassicaceae), were selected for detailed investigation of their angiopreventive potential and mechanisms involved in the inhibition of angiogenesis. Representative targets included effects at the transcriptional levels of pro-angiogenic factors, anti-gelatinolytic and anti-endothelial activity. In vivo, XN was shown to exhibit a strong anti-tumour potency on human breast cancer xenografts mediated by the…    
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Book details

List price: $76.00
Copyright year: 2008
Publisher: .AV Akademikerverlag GmbH & Co. KG
Binding: Paperback
Pages: 132
Size: 6.00" wide x 9.00" long x 0.28" tall
Weight: 0.440
Language: English