Iron Acquisition by the Genus Mycobacterium History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development

ISBN-10: 331900302X
ISBN-13: 9783319003023
Edition: 2013
Authors: B. Rowe Byers
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Description: Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of  More...

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Book details

List price: $49.99
Copyright year: 2013
Publisher: Springer
Publication date: 6/3/2013
Binding: Paperback
Pages: 92
Size: 6.00" wide x 9.00" long x 0.25" tall
Weight: 0.352
Language: English

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

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