Basic Concepts in Medicinal Chemistry

ISBN-10: 1585282669
ISBN-13: 9781585282661
Edition: 2013
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Description: Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these  More...

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Book details

List price: $60.00
Copyright year: 2013
Publisher: American Society of Health-System Pharmacists
Publication date: 1/18/2013
Binding: Paperback
Pages: 460
Size: 7.00" wide x 9.75" long x 0.75" tall
Weight: 2.024
Language: English

Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: * Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. * How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. * Numerous examples and expanded discussions for complex concepts. * Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. * An overview of structure activity relationships (SARs) and concepts that govern drug design. * Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry.

Acknowledgments
Preface
Abbreviations Used in This Text
About the Authors
Introduction
Functional Group Characteristics and Roles
Identifying Acidic and Basic Functional Groups
Solving pH and pK<sub>a</sub> Problems
Salts and Solubility
Drug Binding Interactions
Stereochemistry and Drug Action
Drug Metabolism
Structure Activity Relationships and Basic Concepts in Drug Design
Appendix: Questions and Answers
Index

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