Basic Transport Phenomena in Biomedical Engineering

ISBN-10: 1439826706
ISBN-13: 9781439826706
Edition: 3rd 2012 (Revised)
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Description: This book aims to develop engineering problem solving skills while incorporating a focused treatment of key life science concepts. Based on new material added to his own courses, the author discusses these concepts as they can be applied to the  More...

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Book details

List price: $61.99
Edition: 3rd
Copyright year: 2012
Publisher: CRC Press LLC
Publication date: 8/26/2011
Binding: Hardcover
Pages: 483
Size: 7.25" wide x 10.25" long x 1.00" tall
Weight: 2.530
Language: English

This book aims to develop engineering problem solving skills while incorporating a focused treatment of key life science concepts. Based on new material added to his own courses, the author discusses these concepts as they can be applied to the development and design of biomedical devices. The third edition of this text features updated information in each chapter that reflects the latest research on topics such as thermodynamics, cell membranes, body fluids, bioartificial organs, biological systems, extracorporeal devices, tissue engineering, pharmacokinetic analysis, and more. The text also includes new problems as well as additional examples.

Preface
Author
Notation
Introduction
Review of Units and Dimensions
Units
Fundamental Dimensions
Mass and Weight
Temperature
Mole
Derived Dimensional Quantities
Pressure
Volume
Equations of State
Dimensional Equation
Tips for Solving Engineering Problems
Conservation of Mass
Law of Conservation
Chemical Reactions
Material Balances
Problems
A Review of Thermodynamic Concepts
First Law of Thermodynamics
Closed Systems
Steady Flow Processes
Second Law of Thermodynamics
Reversible Processes
Properties
Heat Capacity
Calculating the Change in Entropy
Entropy Change of an Ideal Gas
Gibbs and Helmholtz Free Energy
Gibbs Free Energy
Helmholtz Free Energy
Fundamental Property Relations
Exact Differentials
Single Phase Open Systems
Partial Molar Properties
Binary Systems
Property Changes of Mixing
Ideal Gas
Gibbs Free Energy of an Ideal Gas Mixture
Pure Component Fugacity
Calculating the Pure Component Fugacity
Fugacity of a Component in a Mixture
Ideal Solution
Phase Equilibrium
Pure Component Phase Equilibrium
Fugacity of a Pure Component as a Compressed Liquid
Excess Properties
Applications of Equilibrium Thermodynamics
Solubility of a Solid in a Liquid Solvent
Depression of the Freezing Point of a Solvent by a Solute
Equilibrium between a Solid and a Gas Phase
Solubility of a Gas in a Liquid
Osmotic Pressure
Distribution of a Solute between Two Liquid Phases
Vapor-Liquid Equilibrium
Flammability Limits
Thermodynamics of Surfaces
Equilibrium Dialysis
Gibbs-Donnan Effect
Donnan Potential
Chemical Equilibrium in Ideal Aqueous Solutions
Problems
Physical Properties of the Body Fluids and the Cell Membrane
Body Fluids
Fluid Compositions
Capillary Plasma Protein Retention
Osmotic Pressure
Osmolarity
Calculating the Osmotic Pressure
Other Factors That May Affect the Osmotic Pressure
Formation of the Interstitial Fluid
Net Capillary Filtration Rate
Lymphatic System
Solute Transport across the Capillary Endothelium
Cell Membrane
Ion Pumps
Problems
The Physical and Flow Properties of Blood and Other Fluids
Physical Properties of Blood
Cellular Components
Rheology
Relationship between Shear Stress and Shear Rate
Hagen-Poiseuille Equation
Other Useful Flow Relationships
Rheology of Blood
Casson Equation
Using the Casson Equation
Velocity Profile for Tube Flow of a Casson Fluid
Tube Flow of Blood at Low Shear Rates
Effect of Diameter at High Shear Rates
Marginal Zone Theory
Using the Marginal Zone Theory
Boundary Layer Theory
Flow near a Wall That is Set in Motion
Laminar Flow of a Fluid along a Flat Plate
Generalized Mechanical Energy Balance Equation
Capillary Rise and Capillary Action
Equilibrium Capillary Rise
Dynamics of Capillary Action
Problems
Solute Transport in Biological Systems
Description of Solute Transport in Biological Systems
Capillary Properties
Capillary Flow Rates
Solute Diffusion
Fick's First Law and Diffusivity
Fick's Second Law
Solution for the Concentration Profile for Diffusion from a Flat Plate into a Quiescent Fluid
Definition of the Solute Flux
Definition of the Mass Transfer Coefficient
Mass Transfer in Laminar Boundary Layer Flow over a Flat Plate
Mass Transfer from the Walls of a Tube Containing a Fluid in Laminar Flow
Mass Transfer Coefficient Correlations
Solute Transport by Capillary Filtration
Solute Diffusion within Heterogeneous Media
Diffusion of a Solute from a Polymeric Material
A Solution Valid for Short Contact Times
Diffusion in Blood and Tissue
Solute Permeability
Irreversible Thermodynamics of Membrane Transport
Finding L<sub>P</sub>,P<sub>m</sub>, and �
Multicomponent Membrane Transport
Transport of Solutes across the Capillary Wall
Transport of a Solute between a Capillary and the Surrounding Tissue Space
The Krogh Tissue Cylinder
A Model of the Krogh Tissue Cylinder
Comparison of Convection and Diffusion Effects
The Renkin-Crone Equation
Determining the Value of P<sub>m</sub>S
Solute Transport in Vascular Beds, the Well-Mixed Assumption
Problems
Oxygen Transport in Biological Systems
Diffusion of Oxygen in Multicellular Systems
Hemoglobin
Oxygen-Hemoglobin Dissociation Curve
Oxygen Levels in Blood
The Hill Equation
Other Factors That Can Affect the Oxygen Dissociation Curve
Tissue Oxygenation
Oxygen Transport in Bioartificial Organs and Tissue-Engineered Constructs
Steady State Oxygen Transport in a Perfusion Bioreactor
Oxygen Transport in the Krogh Tissue Cylinder
Approximate Solution for Oxygen Transport in the Krogh Tissue Cylinder
Artificial Blood
Problems
Pharmacokinetic Analysis
Terminology
Entry Routes for Drugs
Modeling Approaches
Factors Affecting Drug Distribution
Drug Distribution Volumes
Drug Metabolism
Renal Excretion of the Drug
Drug Clearance
Renal Clearance
Plasma Clearance
Biological Half-Life
Model for Intravenous Injection of Drug
Accumulation of Drug in the Urine
Constant Infusion of Drug
Application to Controlled Release of Drugs by Osmotic Pumps
Application to the Transdermal Delivery of Drugs
Predicting the Permeability of Skin
First Order Drag Absorption and Elimination
Two Compartment Model
Two Compartment Model for an Intravenous Injection
Two Compartment Model for First Order Absorption
Problems
Extracorporeal Devices
Applications
Contacting Schemes
Membrane Solute Transport
Estimating the Mass Transfer Coefficients
Estimating the Solute Diffusivity in Blood
Hemodialysis
Background
Dialysate Composition
Role of Ultrafiltration
Clearance and Dialysance
Solute Transfer
Single Compartment Model of Urea Dialysis
Peritoneal Dialysis
Aquapheresis
Blood Oxygenators
Background
Operating Characteristics of Blood Oxygenators
Types of Oxygenators
Analysis of a Membrane Oxygenator, Oxygen Transfer
Analysis of a Membrane Oxygenator, Carbon Dioxide Transfer
Example Calculations for Membrane Oxygenators
Immobilized Enzyme Reactors
Background
Examples of Medical Application of Immobilized Enzymes
Enzyme Reaction Kinetics
Reaction and Diffusion in Immobilized Enzyme Systems
Solving the Immobilized Enzyme Reaction-Diffusion Model
Special Case of a First Order Reaction
Observed Reaction Rate
External Mass Transfer Resistance
Reactor Design Equations
Packed Bed Reactor
Well-Mixed Reactor
Affinity Adsorption
Problems
Tissue Engineering
Introduction
Cell Transplantation
Extracellular Matrix
Glycosaminoglycans
Collagens
Elastin
Fibronectin
Basement Membrane
Cellular Interactions
Cadherins
Selectins
Cell Adhesion Molecules
Integrins
Cytokines and Growth Factors
Polymeric Support Structures
Biocompatibility and Initial Response to an Implant
Tissue Ingrowth in Porous Polymeric Structures
Measuring Blood Flow within Scaffolds Used for Tissue Engineering
Cell Transplantation into Polymeric Support Structures
Bioreactor Design for Tissue Engineering
Problems
Bioartificial Organs
Background
Some Immunology
B Lymphocytes
Antibodies
T Lymphocytes
Interaction between APCs, B Cells, and T Cells
Immune System and Transplanted Cells
Immunoisolation
Permeability of Immunoisolation Membranes
Membrane Sherwood Number
Examples of Bioartificial Organs
Bioartificial Pancreas
Bioartificial Pancreas Approaches
Intravascular Devices
Microencapsulation
Macroencapsulation
Organoid
Number of Islets Needed
Islet Insulin Release Model
Pharmacokinetic Modeling of Glucose and Insulin Interactions
Using the Pharmacokinetic Model to Evaluate the Performance of a Bioartificial Pancreas
Bioartificial Liver
Artificial Liver Systems
Bioartificial Livers
Examples of Extracorporeal Bioartificial Livers
The Bioartificial Kidney
Design Considerations for Bioartificial Organs
Problems
References
Index

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