Engineering Genetic Circuits

ISBN-10: 1420083244
ISBN-13: 9781420083248
Edition: 2011
Authors: Chris J. Myers
List price: $87.95
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Book details

List price: $87.95
Copyright year: 2011
Publisher: CRC Press LLC
Publication date: 7/14/2009
Binding: Hardcover
Pages: 306
Size: 6.50" wide x 9.75" long x 0.75" tall
Weight: 1.298
Language: English

List of Figures
List of Tables
Foreword
Preface
Acknowledgments
An Engineer's Guide to Genetic Circuits
Chemical Reactions
Macromolecules
Genomes
Cells and Their Structure
Genetic Circuits
Viruses
Phage �: A Simple Genetic Circuit
A Genetic Switch
Recognition of Operators and Promoters
The Complete Circuit
Genetic Circuit Models
Why Study Phage �?
Sources
Problems
Appendix
Learning Models
Experimental Methods
Experimental Data
Cluster Analysis
Learning Bayesian Networks
Learning Causal Networks
Experimental Design
Sources
Problems
Differential Equation Analysis
A Classical Chemical Kinetic Model
Differential Equation Simulation
Qualitative ODE Analysis
Spatial Methods
Sources
Problems
Stochastic Analysis
A Stochastic Chemical Kinetic Model
The Chemical Master Equation
Gillespie's Stochastic Simulation Algorithm
Gibson/Bruck's Next Reaction Method
Tau-Leaping
Relationship to Reaction Rate Equations
Stochastic Petri-Nets
Phage � Decision Circuit Example
Spatial Gillespie
Sources
Problems
Reaction-Based Abstraction
Irrelevant Node Elimination
Enzymatic Approximations
Operator Site Reduction
Statistical Thermodynamical Model
Dimerization Reduction
Phage � Decision Circuit Example
Stoichiometry Amplification
Sources
Problems
Logical Abstraction
Logical Encoding
Piecewise Models
Stochastic Finite-State Machines
Markov Chain Analysis
Qualitative Logical Models
Sources
Problems
Genetic Circuit Design
Assembly of Genetic Circuits
Combinational Logic Gates
PoPS Gates
Sequential Logic Circuits
Future Challenges
Sources
Problems
Solutions to Selected Problems
References
Glossary
Index

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