From Neuron to Brain A Cellular and Molecular Approach to the Function of the Nervous System

ISBN-10: 0878934391

ISBN-13: 9780878934393

Edition: 4th 2001

List price: $84.95
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Book details

List price: $84.95
Edition: 4th
Copyright year: 2001
Publisher: Sinauer Associates, Incorporated
Binding: Hardcover
Pages: 580
Size: 8.75" wide x 11.90" long x 1.00" tall
Weight: 2.068
Language: English

Introduction
Principles of Signaling and Organization
Signaling in Simple Neuronal Circuits
Organization of the Retina
Signaling in Nerve Cells
Cellular and Molecular Biology of Neurons
Signals for Development of the Nervous System
Regeneration of the Nervous System after Injury
Signaling in the Nervous System
Ion Channels and Signaling
Properties of Ion Channels
Measurement of Single-Channel Currents
Measuring Channel Conductance
Structure of Ion Channels
The Nicotinic Acetylcholine Receptor
A Receptor Superfamily
Voltage-Activated Channels
Other Channels
Diversity of Subunits
Conclusion
Cloning Receptors and Channels
Classification of Amino Acids
Expression of Receptors and Channels in Xenopus Oocytes
Transport Across Cell Membranes
The Sodium-Potassium Exchange Pump
Calcium Pumps
Sodium-Calcium Exchange
Chloride Transport
Transport of Neurotransmitters
Molecular Structure of Transporters
Significance of Transport Mechanisms
Ionic Basis of the Resting Potential
A Model Cell
Membrane Potentials in Squid Axons
Changes in Membrane Potential
Ionic Basis of the Action Potential
Sodium and Potassium Currents
Voltage Clamp Experiments
Gating Currents
The Role of Calcium in Excitation
The Voltage Clamp
Neurons as Conductors of Electricity
Passive Electrical Properties of Nerve and Muscle Membranes
Propagation of Action Potentials
Conduction in Dendrites
Pathways for Current Flow between Cells
Electrotonic Potentials and the Membrane Time Constant
Classification of Nerve Fibers in Vertebrates
Stimulating and Recording with External Electrodes
Current Flow between Cells
Properties and Functions of Neuroglial Cells
Physiological Properties of Neuroglial Cell Membranes
Functions of Neuroglial Cells
Effects of Neuronal Activity on Glial Cells
Glial Cells and the Blood-Brain Barrier
Glial Cells and Immune Responses of the CNS
The Blood-Brain Barrier
Principles of Direct Synaptic Transmission
Nerve Cells and Synaptic Connections
Electrical Synaptic Transmission
Chemical Synaptic Transmission
Electrical Model of the Motor End Plate
Direct Synaptic Inhibition
Indirect Mechanisms of Synaptic Transmission
Metabotropic Receptors and G Proteins
Direct Modulation of Channel Function by G Proteins
G Protein Activation of Cytoplasmic Second Messenger Systems
Calcium as an Intracellular Second Messenger
Prolonged Time Course of Indirect Transmitter Action
Identifying Responses Mediated by G Proteins
Cyclic AMP as a Second Messenger
Diacylglycerol and IP[subscript 3] as Second Messengers
Formation and Metabolism of Arachidonic Acid
Transmitter Release
Characteristics of Transmitter Release
Quantal Release
Vesicle Hypothesis of Transmitter Release
Synaptic Plasticity
Short-Term Changes in Signaling
Long-Term Changes in Signaling
Cellular and Molecular Biochemistry of Synaptic Transmission
Neurotransmitters
Neurotransmitter Synthesis
Storage of Transmitters in Synaptic Vesicles
Axonal Transport
Transmitter Release and Vesicle Recycling
Transmitter Receptor Localization
Removal of Transmitters from the Synaptic Cleft
The SNARE Hypothesis
Neurotransmitters in the Central Nervous System
Mapping Transmitter Distribution
Peptide Transmitters in the CNS
Regulation of Central Nervous System Function by Biogenic Amines
Molecular Methods and CNS transmitters
Integrative Mechanisms
Cellular Mechanisms of Integration and Behavior in Leeches, Ants, and Bees
From Neurons to Behavior and Vice Versa
Navigation by Ants and Bees
Why Should One Work on Invertebrate Nervous Systems?
Autonomic Nervous System
Functions under Involuntary Control
Synaptic Transmission by Postganglionic Axons
The Path to Understanding Sympathetic Mechanisms
Transduction of Mechanical and Chemical Stimuli
Stimulus Coding by Mechanoreceptors
Transduction of Mechanical Stimuli
Olfaction
Mechanisms of Taste (Gustation)
Transduction of Nociceptive and Thermal Stimuli
Sensory Epithelia of the Inner Ear
Processing of Somatosensory and Auditory Signals
The Somatosensory System: Tactile Recognition
The Auditory System: Encoding Sound Frequency
Brodmann's Areas
Transduction and Signaling in the Retina
The Eye
The Retina
Visual Pigments
Transduction by Photoreceptors
Transmission from Photoreceptors to Bipolar Cells
Receptive Fields of Ganglion Cells
Adaptation of Photoreceptors
Signaling in the Lateral Geniculate Nucleus and the Primary Visual Cortex
The Lateral Geniculate Nucleus
Cytoarchitecture of the Cortex
Strategies for Exploring the Cortex
Functional Architecture of the Visual Cortex
Ocular Dominance Slabs and Orientation Columns
Parallel Processing of Form, Motion, and Color
The Integration of Visual Information
Where Do We Go from Here?
Color Constancy
Corpus Callosum
Cellular Mechanisms of Motor Control
The Motor Unit
Spinal Reflexes
Generation of Coordinated Movement
The Organization of Motor Pathways
Motor Cortex and the Execution of Voluntary Movement
The Cerebellum
The Basal Ganglia
Extracellular Recording of Motor Activity
Development of the Nervous System
Development of the Nervous System
Early Neural Morphogenesis
Regional Specification of Neural Tissue
Determination of Neuronal and Glial Cell Identity
Axon Outgrowth
Axon Guidance
Target Innervation
Synapse Formation
Growth Factors and Survival of Neurons
Competitive Interactions during Development
General Considerations of Neural Specificity
Discovery of Nerve Growth Factor
Denervation and Regeneration of Synaptic Connections
Changes in Axotomized Neurons and the Surrounding Glial Cells
Effects of Denervation on Postsynaptic Cells
Regeneration in the Vertebrate Peripheral Nervous System
Role of Basal Lamina at Regenerating Neuromuscular Synapses
Regeneration in the Mammalian CNS
Critical Periods in Visual and Auditory Systems
The Visual System in Newly Born Monkeys and Kittens
Effects of Abnormal Experience in Early Life
Requirements for Maintenance of Functioning Connections in the Visual System
Cellular and Molecular Mechanisms of Deprivation Changes
Critical Periods in the Auditory System
Critical Periods for Higher Functions
Conclusion
Open Questions
Current Flow in Electrical Circuits
Metabolic Pathways for the Synthesis and Inactivation of Low-Molecular-Weight Transmitters
Structures and Pathways of the Brain
Glossary
Bibliography
Index
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