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| Introduction to Cells | |
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| Light and electron microscopy | |
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| Cells: the principal features of animal, plant, and bacterial cells | |
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| How We Know: Life's common mechanisms | |
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| Chemical Components of Cells | |
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| How We Know: What are macromolecules? | |
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| Chemical bonds and groups | |
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| The chemical properties of water | |
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| An outline of some of the types of sugars | |
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| Fatty acids and other lipids | |
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| The 20 amino acids found in proteins | |
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| A survey of the nucleotides | |
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| The principal types of weak noncovalent bonds | |
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| Energy, Catalysis, and Biosynthesis | |
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| Free energy and biological reactions | |
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| How We Know: Using kinetics to model and manipulate metabolic pathways | |
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| Protein Structure and Function | |
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| A few examples of some general protein functions | |
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| How We Know: Probing protein structure | |
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| Four different ways of depicting a small protein | |
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| Cell breakage and initial fractionation of cell extracts | |
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| Protein separation by chromatography | |
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| Protein separation by electrophoresis | |
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| Making and using antibodies | |
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| DNA and Chromosomes | |
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| How We Know: Genes are made of DNA | |
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| DNA Replication, Repair, and Recombination | |
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| How We Know: Finding replication origins | |
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| From DNA to Protein: How Cells Read the Genome | |
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| How We Know: Cracking the genetic code | |
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| Control of Gene Expression | |
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| How We Know: Gene regulation--the story of eve | |
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| How Genes and Genomes Evolve | |
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| How We Know: Counting genes | |
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| Manipulating Genes and Cells | |
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| How We Know: Sequencing the human genome | |
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| Membrane Structure | |
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| How We Know: Measuring membrane flow | |
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| Membrane Transport | |
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| How We Know: Squid reveal secrets of membrane excitability | |
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| How Cells Obtain Energy from Food | |
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| Details of the 10 steps of glycolysis | |
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| How We Know: Unraveling the citric acid cycle | |
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| The complete citric acid cycle | |
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| Energy Generation in Mitochondria and Chloroplasts | |
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| How We Know: How chemiosmotic coupling drives ATP synthesis | |
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| Redox potentials | |
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| Intracellular Compartments and Transport | |
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| How We Know: Tracking protein and vesicle transport | |
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| Cell Communication | |
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| How We Know: Untangling cell signaling pathways | |
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| Cytoskeleton | |
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| How We Know: Pursuing motor proteins | |
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| Cell-Cycle Control and Cell Death | |
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| How We Know: Discovery of cyclins and Cdks | |
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| Cell Division | |
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| The principal stages of M phase in an animal cell | |
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| How We Know: Building the mitotic spindle | |
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| Genetics, Meiosis, and the Molecular Basis of Heredity | |
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| How We Know: Reading genetic linkage maps | |
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| Some essentials of classical genetics | |
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| Tissues and Cancer | |
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| The cell types and tissues from which higher plants are constructed | |
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| How We Know: Making sense of the genes that are critical for cancer | |
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| Answers to Questions | |
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| Glossary | |
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| Index | |