Protein Crystallography A Concise Guide

ISBN-10: 0801888085
ISBN-13: 9780801888083
Edition: 2008
List price: $40.00 Buy it from $31.95
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Description: The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the  More...

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Book details

List price: $40.00
Copyright year: 2008
Publisher: Johns Hopkins University Press
Publication date: 3/26/2008
Binding: Paperback
Pages: 152
Size: 6.00" wide x 9.00" long x 0.38" tall
Weight: 0.506
Language: English

The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein's three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights. The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure.

Eaton E. Lattman is chair of the Department of Biophysics at the Johns Hopkins University and editor-in-chief of the journal Proteins: Structure, Function, and Genetics. Patrick J. Loll is the director of the Biochemistry Graduate Program at Drexel University College of Medicine.

Preface
Introduction
What Is X-ray Crystallography?
A Quick Look at Protein Crystals
Noncrystalline Specimens
Summary
Further Reading
A Physical Understanding of Diffraction
What Is Diffraction?
Diffraction from One-Dimensional Crystals
Reconstructing Images from Diffraction Patterns
Summary
Further Reading
Diffraction from Three-Dimensional Crystals
The Electron Density Function in Three Dimensions
Calculating the Diffraction Pattern from a Known Structure
Summary
Further Reading
Phase Determination by Isomorphous Replacement
Measuring the Phases
MAD Phasing
Fitting Models to Experimental Electron Density Maps
Summary
Further Reading
The Patterson Function
Definition of the Patterson Function
Using the Patterson Function to Locate Atoms
Summary
Further Reading
Phasing with Partially Known Structures
Difference Fourier Maps
Molecular Replacement
Summary
Further Reading
Crystallographic Refinement
Refinement Improves the Model
Least-Squares Refinement
Summary
Further Reading
Glossary
Index

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