Protein Crystallography A Concise Guide

Name: Protein Crystallography A Concise Guide
Price: 6.74 USD
Availability: InStock
ISBN: 9780801888083

ISBN-10: 0801888085

ISBN-13: 9780801888083

Edition: 2008

Authors: Eaton E. Lattman, Patrick J. Loll

List price: $42.00

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Description:

The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein's three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase…

Book details

List price: $42.00
Copyright year: 2008
Publisher: Johns Hopkins University Press
Publication date: 4/28/2008
Binding: Paperback
Pages: 152
Size: 6.00" wide x 9.00" long x 0.38" tall
Weight: 0.506
Language: English

Eaton E. Lattman is chair of the Department of Biophysics at the Johns Hopkins University and editor-in-chief of the journal Proteins: Structure, Function, and Genetics. Patrick J. Loll is the director of the Biochemistry Graduate Program at Drexel University College of Medicine.



Preface



Introduction



What Is X-ray Crystallography?



A Quick Look at Protein Crystals



Noncrystalline Specimens



Summary


Further Reading



A Physical Understanding of Diffraction



What Is Diffraction?



Diffraction from One-Dimensional Crystals



Reconstructing Images from Diffraction Patterns



Summary


Further Reading



Diffraction from Three-Dimensional Crystals



The Electron Density Function in Three Dimensions



Calculating the Diffraction Pattern from a Known Structure



Summary


Further Reading



Phase Determination by Isomorphous Replacement



Measuring the Phases



MAD Phasing



Fitting Models to Experimental Electron Density Maps



Summary


Further Reading



The Patterson Function



Definition of the Patterson Function



Using the Patterson Function to Locate Atoms



Summary


Further Reading



Phasing with Partially Known Structures



Difference Fourier Maps



Molecular Replacement



Summary


Further Reading



Crystallographic Refinement



Refinement Improves the Model



Least-Squares Refinement



Summary


Further Reading


Glossary


Index