Lehninger Principles of Biochemistry

ISBN-10: 071677108X
ISBN-13: 9780716771081
Edition: 5th 2008
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Book details

List price: $259.99
Edition: 5th
Copyright year: 2008
Publisher: W. H. Freeman & Company
Publication date: 2/1/2008
Binding: Hardcover
Pages: 1100
Size: 8.75" wide x 11.25" long x 1.75" tall
Weight: 6.160
Language: English

The Foundations of Biochemistry
Cellular Foundations
Chemical Foundations
Physical Foundations
Genetic Foundations
Evolutionary Foundations
Molecular Weight, Molecular Mass, and Their Correct Units
Louis Pasteur and Optical Activity: In Vino, Veritas
Entropy: The Advantages of Being Disorganized
Now introduces the concepts of proteomes and proteomics
Updated section on how a new species evolves
Increased emphasis on the interdependence of life forms in global cycles of energy
Structure and Catalysis
Water
Weak Interactions in Aqueous Systems
Ionization of Water, Weak Acids, and Weak Bases
Buffering against pH Changes in Biological Systems
Water as a Reactant
The Fitness of the Aqueous Environment for Living Organisms
Medicine: On Being One's Own Rabbit (Don't Try This at Home!)
Expanded discussion of blood pH buffering by the bicarbonate system,including a new box describing Haldane's use of himself as a guinea pig in experiments aimed at changing the acidity of blood
New section on ketoacidosis in diabetes
Amino Acids, Peptides, and Proteins
Amino Acids
Peptides and Proteins
Working with Proteins
The Structure of Proteins: Primary Structure
Methods: Absorption of Light by Molecules: The Lambert-Beer Law
Methods: Investigating Proteins with Mass Spectrometry
Medicine: Consensus Sequences and Sequence Logos
Significant revision to bioinformatics
More thorough explanation of consensus sequences, including an illustration of common ways to depict consensus sequences
The Three-Dimensional Structure of Proteins
Overview of Protein Structure
Protein Secondary Structure
Protein Tertiary and Quaternary Structures
Protein Denaturation and Folding
Methods: Knowing the Right Hand from the Left
Permanent Waving Is Biochemical Engineering
Medicine: Why Sailors, Explorers, and College Students Should Eat Their Fresh Fruits and Vegetables
The Protein Data Bank
Methods: Methods for Determining the Three-Dimensional Structure of a Protein
Medicine: Death by Misfolding: The Prion Diseases
New section, Defects in protein folding may be the molecular basis for a wide range of human genetic disorders, discusses a variety of amyloid diseases
New section on circular dichroism
Protein Function
Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins
Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins
Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors
Medicine: Carbon Monoxide: A Stealthy Killer
Enzymes
An Introduction to Enzymes
How Enzymes Work
Enzyme Kinetics as an Approach to Understanding Mechanism
Examples of Enzymatic Reactions
Regulatory Enzymes
Transformations of the Michaelis-Menten Equation: The Double-Reciprocal Plot
Kinetic Tests for Determining Inhibition Mechanisms
Evidence for Enzyme-Transition State Complementarity
More explanatory text added to the mechanisms for the enolase and lysozyme reactions
New section on pharmaceuticals developed from an understanding of enzyme mechanism, using penicillin and HIV protease inhibitors as examples
Carbohydrates and Glycobiology
Monosaccharides and Disaccharides
Polysaccharides
Glycoconjugates: Proteoglycans, Glycoproteins, and Glycolipids
Carbohydrates as Informational Molecules: The Sugar Code
Working with Carbohydrates
Medicine: Blood Glucose Measurements in the Diagnosis and Treatment of Diabetes
New medical box, introduces hemoglobin glycation and AGEs and their role in the pathology of advanced diabetes
New section on sugar analogs as drugs that target viral neuraminidase
Introduction to the new field of glycomics, including methods for determining oligosaccharide structure using MALDI-MS
Nucleotides and Nucleic Acids
Some Basics
Nucleic Acid Structure
Nucleic Acid Chemistry
Other Functions of Nucleotides
DNA-Based Information Technologies
DNA Cloning: The Basics
From Genes to Genomes
From Genomes to Proteomes
Genome Alterations and New Products of Biotechnology
Medicine: A Potent Weapon in Forensic Medicine
Medicine: The Human Genome and Human Gene Therapy
New material on the green fluorescent protein
Thorough updating of genomics section
Lipids
Storage Lipids
Structural Lipids in Membranes
Lipids as Signals, Cofactors, and Pigments
Working with Lipids
Sperm Whales: Fatheads of the Deep
Medicine: Abnormal Accumulations of Membrane Lipids: Some Inherited Human Diseases
New medical section on the role of polyunsaturated fatty acids and trans fatty acids in cardiovascular disease
New section on lipidomics
New descriptions of volatile lipids used as signals by plants, and pigments of bird feathers derived from colored lipids in plant foods
Biological Membranes and Transport
The Composition and Architecture of Membranes
Membrane Dynamics
Solute Transport across Membranes
Methods: Atomic Force Microscopy to Visualize Membrane Proteins
Medicine: Defective Glucose and Water Transport in Two Forms of Diabetes
Medicine: A Defective Ion Channel in Cystic Fibrosis
Expanded section on bilayer dynamics covers flippases, floppases, scramblases, and bilayer asymmetry
Expanded and updated section on lipid rafts and caveolae includes new material on membrane curvature and the proteins that influence it, and introduces amphitropic proteins and annular lipids
New information on the structural basis for voltage gating in a K+ channel
Biosignaling
General Features of Signal Transduction
G Protein-Coupled Receptors and Second Messengers
Receptor Tyrosine Kinases
Receptor Guanylyl Cyclases, cGMP, and Protein Kinase G
Multivalent Scaffold Proteins and Membrane Rafts
Gated Ion Channels
Integrins: Bidirectional Cell Adhesion Receptors
Regulation of Transcription by Steroid Hormones
Signaling in Microorganisms and Plants
Sensory Transduction in Vision, Olfaction, and Gustation
Regulation of the Cell Cycle by Protein Kinases
Oncogenes, Tumor Suppressor Genes, and Programmed Cell Death
Methods: Scatchard Analysis Quantifies the Receptor-Ligand Interaction
Medicine: G Proteins: Binary Switches in Health and Disease
Methods: FRET: Biochemistry Visualized in a Living Cell
Medicine: Color Blindness: John Dalton's Experiment from the Grave
Medicine: Development of Protein Kinase Inhibitors for Cancer Treatment
New Medical section on G protein coupled receptors (GCPRs) discusses the range of diseases for which drugs target GPCRs
New box on G proteins, proteins that regulate their GTPase activity, and the medical consequences of defective G protein function
Expanded and integrated treatment of local signaling circuits, including AKAPs and signaling complexes that include protein kinase A, adenylyl cyclase, and phosphodiesterase, and localized puffs and waves of Ca2+
New medical box on the use of protein kinase inhibitors in cancertherapy
Bioenergetics and Metabolism
Bioenergetics and Biochemical Reaction Types
Bioenergetics and Thermodynamics
Chemical Logic and Common Biochemical Reactions
Phosphoryl Group Transfers and ATP
Biological Oxidation-Reduction Reactions
Firefly Flashes: Glowing Reports of ATP
New section, Chemical logic and common biochemical reactions, discusses common biochemical reaction types
Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
Glycolysis
Feeder Pathways for Glycolysis
Fates of Pyruvate under Anaerobic Conditions: Fermentation
Gluconeogenesis
Pentose Phosphate Pathway of Glucose Oxidation
Medicine: High Rate of Glycolysis in Tumors Suggests Targets for Chemotherapy and Facilitates Diagnosis
Athletes, Alligators, and Coelacanths: Glycolysis at Limiting Concentrations of Oxygen
Ethanol Fermentations: Brewing Beer and Producing Biofuels
Medicine: Why Pythagoras Wouldn't Eat Falafel: Glucose 6-Phosphate Dehydrogenase Deficiency
New medical box on glucose uptake deficiency in type 1 diabetes
New medical box on how the high rate of glycolysis in cancerous tissue aids cancer diagnosis and treatment
Principles of Metabolic Regulation
Regulation of Metabolic Pathways
Analysis of Metabolic Control
Coordinated Regulation of Glycolysis and Gluconeogenesis
The Metabolism of Glycogen in Animals
Coordinated Regulation of Glycogen Synthesis and Breakdown
Methods: Metabolic Control Analysis: Quantitative Aspects
Isozymes: Different Proteins That Catalyze the Same Reaction
Medicine: Genetic Mutations That Lead to Rare Forms of Diabetes
Carl and Gerty Cori: Pioneers in Glycogen Metabolism and Disease
New section on emerging role of ribulose 5-phosphate as central regulator of glycolysis and gluconeogenesis
Expanded discussion of phosphoprotein phosphatases in metabolic regulation
Expanded coverage of the role of transcriptional regulators in metabolic regulation
New medical box on mutations that lead to rare forms of diabetes regulation (MODY)
The Citric Acid Cycle
Production of Acetyl-CoA (Activated Acetate)
Reactions of the Citric Acid Cycle
Regulation of the Citric Acid Cycle
The Glyoxylate Cycle
Moonlighting Enzymes: Proteins with More Than One Job
Synthases and Synthetases; Ligases and Lyases; Kinases,Phosphatases, and Phosphorylases: Yes, the Names Are Confusing!
Citrate: A Symmetric Molecule That Reacts Asymmetrically
Citrate Synthase, Soda Pop, and the World Food Supply
New box on effect of diabetes on the citric acid cycle and ketone body formation
Expanded discussion of substrate channeling
New section on mutations in citric acid cycle that lead to cancer
New box on moonlighting enzymes
Fatty Acid Catabolism
Digestion, Mobilization, and Transport of Fats
Oxidation of Fatty Acids
Ketone Bodies
Fat Bears Carry Out b Oxidation in Their Sleep
Coenzyme B12: A Radical Solution to a Perplexing Problem
New section on the role of transcription factors (PPARs) in regulation of lipid catabolism
Amino Acid Oxidation and the Production of Urea
Metabolic Fates of Amino Groups
Nitrogen Excretion and the Urea Cycle
Pathways of Amino Acid Degradation
Medicine: Assays for Tissue Damage
Medicine: Scientific Sleuths Solve a Murder Mystery
New section on pernicious anemia and associated problems in strict vegetarians.
Oxidative Phosphorylation and Photophosphorylation Oxidative Phosphorylation
Electron-Transfer Reactions in Mitochondria
ATP Synthesis
Regulation of Oxidative Phosphorylation
Mitochondria in Thermogenesis, Steroid Synthesis, and Apoptosis
Mitochondrial Genes: Their Origin and the Effects of Mutations Photosynthesis: Harvesting Light Energy
General Features of Photophosphorylation
Light Absorption
The Central Photochemical Event: Light-Driven Electron Flow
ATP Synthesis by Photophosphorylation
The Evolution of Oxygenic Photosynthesis
Hot, Stinking Plants and Alternative Respiratory Pathways
Updated discussion of the structure of the electron transfer complexes of mitochondria and chloroplasts, and of the Fo complex
Updated description of the water-splitting complex's structure in chloroplasts
Expanded description of mitochondrial diseases and mitochondrial role in diabetes
Carbohydrate Biosynthesis in Plants and Bacteria
Photosynthetic Carbohydrate Synthesis
Photorespiration and the C4 and CAM Pathways
Biosynthesis of Starch and Sucrose
Synthesis of Cell Wall Polysaccharides: Plant Cellulose and Bacterial Peptidoglycan
Integration of Carbohydrate Metabolism in the Plant Cell
Lipid Biosynthesis
Biosynthesis of Fatty Acids and Eicosanoids
Biosynthesis of Triacylglycerols
Biosynthesis of Membrane Phospholipids
Biosynthesis of Cholesterol, Steroids, and Isoprenoids
Mixed-Function Oxidases, Oxygenases, and Cytochrome P-450
Revised and updated section on fatty acid synthase includes new structural information on FAS I
Updated information on cyclooxygenase inhibitors (pain relievers Vioxx, Celebrex, Bextra)
New information on HMG-CoA reductase and new medical box on statins
Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
Overview of Nitrogen Metabolism
Biosynthesis of Amino Acids
Molecules Derived from Amino Acids
Biosynthesis and Degradation of Nucleotides
Unusual lifestyles of the obscure but abundant
Medicine: On Kings and Vampires
Medicine: Curing African Sleeping Sickness with a Biochemical Trojan Horse
Updated coverage of nitrogen cycle section includes a new box on anammox bacteria
New information on therapy for acute lymphoblastic leukemia
New information on folic acid deficiency
Hormonal Regulation and Integration of Mammalian Metabolism
Hormones: Diverse Structures for Diverse Functions
Tissue-Specific Metabolism: The Division of Labor
Hormonal Regulation of Fuel Metabolism
Obesity and the Regulation of Body Mass
Obesity, the Metabolic Syndrome, and Type 2 Diabetes
Medicine: How Is a Hormone Discovered? The Arduous Path to Purified Insulin
Expanded coverage and updating of the biochemical connections between obesity, metabolic syndrome, and type 2 diabetes
Updated discussion of the integration of fuel metabolism in fed and starved states in diabetes
Information Pathways
Genes and Chromosomes
Chromosomal Elements
DNA Supercoiling
The Structure of Chromosomes
Medicine: Curing Disease by Inhibiting Topoisomerases
Medicine: Epigenetics, Nucleosome Structure, and Histone Variants
New material on histone modification, histone variants, and nucleosome deposition
New medical box on the use of topoisomerase inhibitors in the treatment of bacterial infections and cancer, includes material on ciprofloxacin (the antibiotic effective for anthrax)
New box on the role of histone modification and nucleosome deposition in the transmission of epigenetic information in heredity
DNA Metabolism
DNA Replication
DNA Repair
DNA Recombination
Medicine: DNA Repair and Cancer
New information on the initiation of replication and the dynamics at the replication fork, introducing AAA+ ATPases and their functions in replication and other aspects of DNA metabolism
RNA Metabolism
DNA-Dependent Synthesis of RNA
RNA Processing
RNA-Dependent Synthesis of RNA and DNA
Methods: RNA Polymerase Leaves Its Footprint on a Promoter
Fighting AIDS with Inhibitors of HIV Reverse Transcriptase
Methods: The SELEX Method for Generating RNA Polymers with New Functions
An Expanding RNA Universe Filled with TUF RNAs
New section on the expanding roles of RNA in cells
Protein Metabolism
The Genetic Code
Protein Synthesis
Protein Targeting and Degradation
Exceptions That Prove the Rule: Natural Variations in the Genetic Code
From an RNA World to a Protein World
Natural and Unnatural Expansion of the Genetic Code
Induced Variation in the Genetic Code: Nonsense Suppression
Expanded section on protein synthesis coupled to the advances in ribosome structure
New information on the roles of RNA in protein biosynthesis
Regulation of Gene Expression
Principles of Gene Regulation
Regulation of Gene Expression in Bacteria
Regulation of Gene Expression in Eukaryotes
Of Fins, Wings, Beaks, and Things
New information about roles of RNA in gene regulation
New box on the connections between evolution and development
Common Abbreviations in the Biochemical Research Literature
Abbreviated Solutions to Problems
Glossary
Credits
Index

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