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Preface | |
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Acknowledgments | |
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Introduction to Longitudinal and Clustered Data | |
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Longitudinal and Clustered Data | |
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Introduction | |
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Longitudinal and Clustered Data | |
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Examples | |
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Regression Models for Correlated Responses | |
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Organization of This Book | |
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Further Reading | |
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Longitudinal Data: Basic Concepts | |
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Introduction | |
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Objectives of Longitudinal Analysis | |
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Defining Features of Longitudinal Data | |
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Example: Treatment of Lead-Exposed Children Trial | |
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Sources of Correlation in Longitudinal Data | |
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Further Reading | |
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Problems | |
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Linear Models for Longitudinal Continuous Data | |
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Overview of Linear Models for Longitudinal Data | |
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Introduction | |
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Notation and Distributional Assumptions | |
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Simple Descriptive Methods of Analysis | |
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Modelling the Mean | |
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Modelling the Covariance | |
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Historical Approaches | |
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Further Reading | |
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Estimation and Statistical Inference | |
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Introduction | |
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Estimation: Maximum Likelihood | |
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Missing Data Issues | |
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Statistical Inference | |
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Restricted Maximum Likelihood (REML) Estimation | |
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Further Reading | |
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Modelling the Mean: Analyzing Response Profiles | |
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Introduction | |
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Hypotheses Concerning Response Profiles | |
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General Linear Model Formulation | |
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Case Study | |
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One-Degree-of-Freedom Tests for Group by Time Interaction | |
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Adjustment for Baseline Response | |
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Alternative Methods of Adjusting for Baseline Response | |
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Strengths and Weaknesses of Analyzing Response Profiles | |
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Computing: Analyzing Response Profiles Using PROC MIXED in SAS | |
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Further Reading | |
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Problems | |
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Modelling the Mean: Parametric Curves | |
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Introduction | |
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Polynomial Trends in Time | |
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Linear Splines | |
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General Linear Model Formulation | |
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Case Studies | |
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Computing: Fitting Parametric Curves Using PROC MIXED in SAS | |
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Further Reading | |
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Problems | |
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Modelling the Covariance | |
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Introduction | |
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Implications of Correlation among Longitudinal Data | |
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Unstructured Covariance | |
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Covariance Pattern Models | |
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Choice among Covariance Pattern Models | |
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Case Study | |
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Discussion: Strengths and Weaknesses of Covariance Pattern Models | |
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Computing: Fitting Covariance Pattern Models Using PROC MIXED in SAS | |
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Further Reading | |
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Problems | |
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Linear Mixed Effects Models | |
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Introduction | |
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Linear Mixed Effects Models | |
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Random Effects Covariance Structure | |
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Two-Stage Random Effects Formulation | |
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Choice among Random Effects Covariance Models | |
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Prediction of Random Effects | |
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Prediction and Shrinkage | |
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Case Studies | |
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Computing: Fitting Linear Mixed Effects Models Using PROC MIXED in SAS | |
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Further Reading | |
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Problems | |
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Residual Analyses and Diagnostics | |
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Introduction | |
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Residuals | |
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Transformed Residuals | |
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Semi-Variogram | |
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Case Study | |
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Summary | |
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Further Reading | |
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Problems | |
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Generalized Linear Models for Longitudinal Data | |
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Review of Generalized Linear Models | |
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Introduction | |
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Salient Features of Generalized Linear Models | |
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Illustrative Examples | |
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Computing: Fitting Generalized Linear Models Using PROC GENMOD in SAS | |
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Overview of Generalized Linear Models | |
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Further Reading | |
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Problems | |
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Marginal Models: Generalized Estimating Equations (GEE) | |
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Introduction | |
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Marginal Models for Longitudinal Data | |
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Estimation for Marginal Models: Generalized Estimating Equations | |
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Case Studies | |
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Computing: Generalized Estimating Equations Using PROC GENMOD in SAS | |
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Distributional Assumptions for Marginal Models | |
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Further Reading | |
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Problems | |
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Generalized Linear Mixed Effects Models | |
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Introduction | |
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Incorporating Random Effects in Generalized Linear Models | |
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Interpretation of Regression Parameters | |
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Estimation and Inference | |
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Case Studies | |
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Computing: Fitting Generalized Linear Mixed Models Using PROC NLNIXED in SAS | |
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Further Reading | |
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Problems | |
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Contrasting Marginal and Mixed Effects Models | |
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Introduction | |
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Linear Models: A Special Case | |
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Generalized Linear Models | |
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Simple Numerical Illustration | |
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Case Study | |
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Conclusion | |
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Further Reading | |
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Advanced Topics for Longitudinal and Clustered Data | |
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Missing Data and Dropout | |
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Introduction | |
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Hierarchy of Missing Data Mechanisms | |
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Implications for Longitudinal Analysis | |
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Dropout | |
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Common Approaches for Handling Dropout | |
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Case Study | |
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Further Reading | |
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Some Aspects of the Design of Longitudinal Studies | |
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Introduction | |
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Sample Size and Power | |
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Interpretation of Stochastic Time-Varying Covariates | |
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Longitudinal and Cross-Sectional Information | |
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Further Reading | |
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Repeated Measures and Related Designs | |
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Introduction | |
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Repeated Measures Designs | |
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Multiple Source Data | |
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Case Study 1: Repeated Measures Experiment | |
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Case Study 2: Multiple Source Data | |
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Summary | |
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Further Reading | |
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Multilevel Models | |
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Introduction | |
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Multilevel Data | |
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Multilevel Linear Models | |
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Multilevel Generalized Linear Models | |
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Summary | |
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Further Reading | |
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Gentle Introduction to Vectors and Matrices | |
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Properties of Expectations and Variances | |
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Critical Points for a 50:50 Mixture of Chi-Squared Distributions | |
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References | |
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Index | |