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| Preface to the third edition | |
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| Acknowledgements to the third edition | |
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| Figure key | |
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| SI/mass unit conversions | |
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| Acids, bases and pH | |
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| Acids, bases and hydrogen ions (protons) | |
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| Understanding pH | |
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| Production and removal of protons into and from the blood | |
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| Metabolic alkalosis and metabolic acidosis | |
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| Respiratory alkalosis and respiratory acidosis | |
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| Structure of amino acids and proteins | |
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| Amino acids and the primary structure of proteins | |
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| Secondary structure of proteins | |
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| Tertiary and quaternary structure and collagen | |
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| Formation of ATP: oxidation and reduction reactions | |
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| Oxidation/reduction reactions, coenzymes and prosthetic groups | |
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| Anaerobic production of ATP by substrate-level phosphorylation, from phosphocreatine and by the adenylate kinase (myokinase) reaction | |
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| Aerobic production of ATP | |
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| Biosynthesis of ATP by oxidative phosphorylation I | |
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| Biosynthesis of ATP by oxidative phosphorylation II | |
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| What happens when protons or electrons leak from the respiratory chain? | |
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| Free radicals, reactive oxygen species and oxidative damage | |
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| Aerobic oxidation of glucose to provide energy as ATP | |
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| Anaerobic oxidation of glucose by glycolysis to form ATP and lactate | |
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| Anaerobic glycolysis in red blood cells, 2,3-BPG (2,3-DPG) and the Bohr effect | |
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| Carbohydrates | |
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| Carbohydrates | |
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| Absorption of carbohydrates and metabolism of galactose | |
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| Fate of glucose in liver: glycogenesis and lipogenesis | |
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| Fructose metabolism | |
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| Glucose homeostasis | |
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| Glucose-stimulated secretion of insulin from �-cells | |
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| Regulation of glycogen metabolism | |
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| Glycogen breakdown (glycogenolysis) and glycogen storage diseases | |
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| Insulin signal transduction and diabetes mellitus | |
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| Diabetes mellitus | |
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| Alcohol metabolism: hypoglycaemia, hyperlactataemia and steatosis | |
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| Enzymes and regulation of pathways | |
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| Enzymes: nomenclature, kinetics and inhibitors | |
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| Regulation of enzyme activity | |
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| Regulation of glycolysis and Krebs cycle | |
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| Oxidation of fatty acids to produce ATP in muscle and ketone bodies in liver | |
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| Regulation of lipolysis, �-oxidation, ketogenesis and gluconeogenesis | |
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| Lipids and lipid metabolism | |
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| Structure of lipids | |
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| Phospholipids I: phospholipids and sphingolipids | |
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| Phospholipids II: micelles, liposomes, lipoproteins and membranes | |
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| Metabolism of carbohydrate to cholesterol | |
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| VLDL and LDL metabolism I: "forward" cholesterol transport | |
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| VLDL and LDL metabolism II: endogenous triacylglycerol transport | |
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| HDL metabolism: "reverse" cholesterol transport | |
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| Absorption and disposal of dietary triacylglycerols and cholesterol by chylomicrons | |
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| Steroid hormones: aldosterone, cortisol, androgens and oestrogens | |
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| Metabolism of amino acids and porphyrins | |
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| Urea cycle and overview of amino acid catabolism | |
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| Non-essential and essential amino acids | |
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| Amino acid metabolism: to energy as ATP; to glucose and ketone bodies | |
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| Amino acid disorders: maple syrup urine disease, homocystinuria, cystinuria, alkaptonuria and albinism | |
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| Phenylalanine and tyrosine metabolism in health and disease | |
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| Products of tryptophan and histidine metabolism | |
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| Haem, bilirubin and porphyria | |
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| Vitamins | |
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| Fat-soluble vitamins I: vitamins A and D | |
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| Fat-soluble vitamins II: vitamins E and K | |
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| Water-soluble vitamins I: thiamin, ribofl avin, niacin and pantothenate | |
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| Water-soluble vitamins II: pyridoxal phosphate (B6) | |
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| Water-soluble vitamins III: folate and vitamin B12 | |
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| Water-soluble vitamins IV: biotin and vitamin C | |
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| Molecular biology | |
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| The cell cycle | |
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| Pyrimidine metabolism | |
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| Purine metabolism | |
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| Structure of DNA | |
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| The "central dogma" of molecular biology | |
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| Organisation of DNA in chromosomes | |
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| Replication of DNA (part 1) | |
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| Replication of DNA (part 2) | |
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| DNA damage and repair | |
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| Transcription of DNA to make messenger RNA (part 1) | |
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| Transcription of DNA to make messenger RNA (part 2) | |
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| Transcription of DNA to make transfer RNA | |
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| Transcription of DNA to make ribosomal RNA | |
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| Translation and protein synthesis | |
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| Comparison of DNA replication, DNA transcription and protein synthesis in eukaryotes and prokaryotes | |
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| Diagnostic clinical biochemistry | |
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| Diagnostic clinical biochemistry | |
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| Index | |