Fundamentals of Heterocyclic Chemistry Importance in Nature and in the Synthesis of Pharmaceuticals

ISBN-10: 0470566698
ISBN-13: 9780470566695
Edition: 2010
List price: $96.95
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Description: Heterocyclic chemistry is of prime importance as a sub-discipline of Organic Chemistry, as millions of heterocyclic compounds are known with more being synthesized regularly Introduces students to heterocyclic chemistry and synthesis with practical  More...

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Book details

List price: $96.95
Copyright year: 2010
Publisher: John Wiley & Sons, Incorporated
Publication date: 8/9/2010
Binding: Hardcover
Pages: 344
Size: 6.22" wide x 9.30" long x 0.98" tall
Weight: 1.342
Language: English

Heterocyclic chemistry is of prime importance as a sub-discipline of Organic Chemistry, as millions of heterocyclic compounds are known with more being synthesized regularly Introduces students to heterocyclic chemistry and synthesis with practical examples of applied methodology Emphasizes natural product and pharmaceutical applications Provides graduate students and researchers in the pharmaceutical and related sciences with a background in the field Includes problem sets with several chapters

LOUIS D. QUIN, PhD, is an Adjunct Professor at the University of North Carolina Wilmington. Dr. Quin began his academic career in 1956 with the Department of Chemis-try at Duke University, serving as department chairman from 1970 to 1976. After retiring from Duke, he went to the University of Massachusetts Amherst to head up its Chemistry Department, retiring in 1996. Dr. Quin has written 250 research papers and written or co-edited eight books on the subject of organophosphorus chemistry.JOHN A. TYRELL, PhD, is Visiting Scientist in the Department of Chemistry and Bio-chemistry at the University of North Carolina Wilmington, where he teaches Fundamentals of Heterocyclic Chemistry among other courses. Dr. Tyrell holds sixty-eight patents and has more than twenty years of industrial research experience, much of it focused on heterocyclic chemistry research at Lederle Laboratories, General Electric Plastics, and OxyChem.

Preface
Acknowledgment
The Scope of the Field of Heterocyclic Chemistry
References
Appendix
Common Ring Systems and the Naming of Heterocyclic Compounds
General
Naming Simple Monocyclic Compounds
Handling the "Extra Hydrogen"
Substituted Monocyclic Compounds
Rings With More Than One Heteroatom
Bicyclic Compounds
Multicyclic Systems
The Replacement Nomenclature System
Saturated Bridged Ring Systems
References
Review Exercises
Nature as A Source of Heterocyclic Compounds
General
Naturally Occurring Nitrogen Heterocyclic Compounds
Oxygen Compounds
Sulfur and Phosphorus Heterocyclic Compounds in Nature
References
Principles of Synthesis of Aromatic Heterocycles by Intramolecular Cyclization
General
Some of the Classic Synthetic Methods
Cyclizations Involving Metallic Complexes as Catalysts
Cyclizations with Radical Intermediates
Cyclizations by Intramolecular Wittig Reactions
Synthesis of Heterocycles by the Alkene Metathesis Reaction
References
Review Exercises
Synthesis of Heterocyclic Systems By Cycloaddition Reactions
The Diels-Alder Reaction
Dipolar Cycloadditions
[2 + 2] Cycloadditions
References
Review Exercises
Aromaticity and Other Special Properties of Heterocycles: Pi-Deficient Ring Systems
General
Review of the Aromaticity of Benzene
Pi-Deficient Aromatic Heterocycles
References
Review Exercises
Aromaticity And Other Special Properties of Heterocycles: Pi-Excessive Ring Systems and Mesoionic Ring Systems
Pi-Excessive Aromatic Heterocycles
Mesoionic Heterocycles
References
Review Exercises
The Importance of Heterocycles in Medicine
General
Historical
Pyridines
Indoles
Quinolines
Azepines
Pyrimidines
Concluding Remarks
References
Synthetic Methods for Some Prominent Heterocyclic Families: Examples of Pharmaceuticals Synthesis
Scope of the Chapter
Pyrroles
Furans
Thiophenes
1,3-Thiazoles
1,3-Oxazoles
Imidazoles
Pyrazoles
1,2,4-Triazoles
Tetrazoles
1,3,4-Thiadiazoles and other 5-Membered Systems
Indole
Pyridines
Quinolines and Isoquinolines
Benzodiazepines
Pyrimidines
Fused Pyrimidines: Purines and Pteridines
1,3,5-Triazines
Multicyclic Compounds
References
Review Exercises
Geometric and Stereochemical Aspects of Nonaromatic Heterocycles
General
Special Properties of Three-Membered Rings
Closing Heterocyclic Rings: Baldwin's Rules
Conformations of Heterocyclic Rings
Chirality Effects on Biological Properties of Heterocycles
References
Review Exercises
Synthetic Heterocyclic Compounds in Agricultural and Other Applications
Heterocyclic Agrochemicals
Applications of Heterocyclic Compounds in Commercial Fields
References
Appendix: Unified Aromaticity Indices (I<sub>A</sub>) of Bird
Index

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