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Biological Inorganic Chemistry A New Introduction to Molecular Structure and Function

ISBN-10: 0444537821
ISBN-13: 9780444537829
Edition: 2nd 2012
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Description: The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic  More...

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Book details

Edition: 2nd
Copyright year: 2012
Publisher: Elsevier
Publication date: 2/7/2012
Binding: Paperback
Pages: 472
Size: 7.75" wide x 9.50" long x 1.00" tall
Weight: 2.420
Language: English

The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. This revised and expanded text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten, chromium and selected non-metals. The final five chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment.Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on.Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject.Many colour illustrations. Enables easier visualization of molecular mechanismsWritten by a single author. Ensures homgeneity of style and effective cross referencing between chapters

Unit� de Biochimie, Universit� Catholique de Louvain, Louvain-la-Neuve, Belgium Prof. Crichton, originally from the UK, is well known in the inorganic biology community and is invited to speak at many international conferences. He has published 3 books in this area (others on biochemistry of iron and metal-based neruodegeneration) and has taught over 750 doctoral and post-doctoral students. The book contains an essential distillation of the knowledge and material he had used to teach and lecture over many years.

The role of metals in biology - an overview
Basic coordination chemistry for biologists
Structural and molecular biology for chemists
Biological ligands for metal ions
An overview of intermediary metabolism and bioenergetics
Methods which can be used to study metals in biology
Metal assimilation pathways
Transport, storage and homeostasis of metal ions
Sodium and potassium
Calcium
Magnesium
Zinc
Iron
Copper
Nickel and cobalt
Manganese
Molybdenum, vanadium, tungsten and chromium
Metals in brain function
Biomineralisation
Metals in medicine and the environment
Concluding remarks

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