Lu's Basic Toxicology

ISBN-10: 0415248566
ISBN-13: 9780415248563
Edition: 4th 2002 (Revised)
Author(s): Frank C. Lu, Sam Kacew
Description: This volume provides a concise and comprehensive treatment of modern toxicology. Topics covered include, toxic substances, general principles of toxicology and inhalation toxicology.
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List Price: $59.95
Edition: 4th
Copyright Year: 2002
Publisher: CRC Press LLC
Publication Date: 5/23/2002
Binding: Paperback
Pages: 392
Size: 6.00" wide x 9.00" long x 1.00" tall
Weight: 1.386
Language: English

This volume provides a concise and comprehensive treatment of modern toxicology. Topics covered include, toxic substances, general principles of toxicology and inhalation toxicology.

About the authors
Preface
General principles of toxicology
General considerations
Definition and purpose of toxicology
Scope and subdisciplines
Early developments
Recent developments
Some challenges and successes
Toxicity vs. other considerations
Future prospects
References
U.S. laws that have a basis in toxicology
Examples of outbreaks of mass poisoning
Absorption, distribution, and excretion of toxicants
Introduction
Absorption
Distribution
Excretion
Levels of toxicants in the body
References
Biotransformation of toxicants
General considerations
Phase I (degradation) reactions
Phase II (conjugation) reactions
Bioactivation
Complex nature of biotransformation
References
Examples of bioactivation
Toxic effects
General considerations
Spectrum of toxic effects
Target organs
Mechanisms of action
Molecular targets: chemical nature
Receptors
References
Modifying factors of toxic effects
General considerations
Host factors
Environmental factors
Chemical interaction
References
Mechanisms underlying certain modifying factors
Strain-related differences in drug-induced responses
Testing procedures for conventional and nontarget organ toxicities
Conventional toxicity studies
Introduction
Acute toxicity studies
Short-term and long-term toxicity studies
Good laboratory practice
References
Additional reading
General observations, clinical laboratory tests, and pathology examinations that may be used in short- and long-term toxicity studies
Carcinogenesis
Introduction
Mode of action
Categories of carcinogens
Some human carcinogens/target organs
Tests for carcinogenicity
Evaluation
References
Additional reading
Probable carcinogenic chemicals
Biomarkers of carcinogenesis/human cancers
Mutagenesis
Introduction
Gene mutation
Chromosomal effects
DNA repair and recombination
Other tests
Evaluation
References
Developmental toxicology
Introduction
Teratogens (developmental toxicants) and their effects
Mode of action
Teratogens of special interest
Testing procedures
Evaluation of teratogenic effects
References
Teratogens in animal models
Lactation
General remarks
Benefits of breast-feeding
Toxicants
References
Target organs and systems
Toxicology of the immune system
General considerations
Components of the system
Immunotoxicants
Immunotoxicities: testing procedures
Evaluation
References
Additional reading
Respiratory system: inhalation toxicology
Introduction
Toxicants and their effects
Testing procedures
Evaluation
References
Site of action and pulmonary disease produced by selected occupationally inhaled toxicants
Mechanisms underlying the oxidative stress induced by cigarette smoke
Toxicology of the liver
General considerations
Types of liver injury
Hepatotoxicants
Testing procedures
Evaluation
References
Examples of hepatotoxic agents and associated liver injury
Toxicology of the kidney
Introduction
Nephrotoxicants: mechanism and site of action
Testing procedure
Evaluation
References
Additional reading
Toxicology of the skin
General considerations
Types of toxic effects and dermatotoxicants
Testing procedures
Evaluation
In vitro tests
References
Primary irritation
Toxicology of the eye
General considerations
Toxicants and site of their effects
Testing procedures
Evaluation
References
Cataractogenic chemicals
Grading of eye irritation
Toxicology of the nervous system
Introduction
Neurotoxic effects and neurotoxicants
Testing procedures
Behavioral studies: testing procedures
Evaluation
References
Select neurotoxicants described in text
Reproductive and cardiovascular systems
Reproductive system
Introduction
Toxicants and their effects
Routine testing: multigeneration reproduction studies
Other tests
Cardiovascular system
General considerations
Toxic effects on the heart
Toxic effects on blood vessels
Testing procedures
References
Toxic substances and risk assessment
Food additives and contaminants
Introduction
Toxicological testing and evaluation
Additives of toxicological concern
Indirect additives and contaminants
Contaminants
References
Major functional groups of direct food additives
Toxicity of pesticides
Introduction
Categories of pesticides
Toxicological properties
Testing, evaluation, and control
Gulf War Syndrome
References
Toxicological findings and evaluation on certain insecticides
Toxicity of metals
Introduction
Certain common features
Common toxic effects
Metals of major toxicological concern
Risk/benefit considerations
References
Over-the-counter preparations
General remarks
Prevalence in society
Adverse consequences
References
Environmental pollutants
General remarks
Air pollutants
Water and soil pollutants
References
Occupational toxicology
General remarks
Exposure limits
Occupational toxicants
Monitoring
References
Acute pesticide toxicity, general signs and symptoms in humans
Toxicologic evaluation: assessment of safety/risk
Introduction
Major approaches
Acceptable daily intake (ADI/RfD)/safety assessment
Mathematical models/risk assessment
Other procedures
International activities in toxicological evaluation
References
Chemical index
Subject index

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