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| Preface | |
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| Abbreviations | |
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| VEGF and Its Receptors | |
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| Activities of VEGF | |
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| VEGF Isoforms | |
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| Regulation of VEGF Gene Expression | |
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| The VEGF Receptors | |
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| Role of VEGF in Physiological Angiogenesis | |
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| Role of VEGF in Pathologic Conditions | |
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| Therapeutic Implications and Perspectives | |
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| Hypoxic Regulation of VEGF | |
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| Transcriptional Regulation of VEGF | |
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| Post Transcriptional Regulation of VEGF | |
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| Abnormalities in the Hypoxic Regulation of VEGF | |
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| Molecular Mechanisms of VEGF-Induced Angiogenesis | |
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| Angiogenesis | |
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| The Role of Vascular Endothelial Growth Factor in Angiogenesis | |
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| The VEGF Signal Cascade in Angiogenesis | |
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| Crosstalk between VEGF and Bcl-2 in Tumor Progression and Angiogenesis | |
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| Angiogenic Potential of Tumor Cells Overexpressing Bcl-2 | |
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| Role of Bcl-2 in VEGF-Promoted Survival of Tumor Cells | |
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| Role of Bcl-2 in Endothelial Cells | |
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| Clinical Relevance of VEGF and Bcl-2 Expression | |
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| Vascular Endothelial Growth Factor in Breast Cancer | |
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| VEGF and Tumor Growth | |
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| Serum VEGF and Breast Cancer | |
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| VEGF and Clinical Consequences | |
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| Future Strategies in Breast Cancer | |
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| VEGF and Tumor Progression in Human Melanoma | |
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| VEGF in Tumor Angiogenesis | |
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| Angiogenesis and Human Melanoma | |
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| VEGF in Human Melanoma | |
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| VEGF in Esophageal Cancer | |
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| VEGF in Squamous Cell Carcinoma of the Esophagus | |
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| VEGF in Barrett's Disease and Adenocarcinoma of the Esophagus | |
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| Circulating VEGF Levels in Esophageal Carcinoma | |
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| VEGF and MVD during Neoadjuvant Treatment of Esophageal Carcinoma | |
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| VEGF-C and Lymphangiogenesis in Esophageal Carcinoma | |
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| Anti-VEGF Treatment of Esophageal Carcinoma | |
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| VEGF in Colorectal Cancer | |
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| Colon Cancer | |
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| VEGF in Colorectal Cancer Progression | |
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| Prognostic Value of VEGF in Colorectal Cancer Patients | |
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| The Role of VEGF in Metastasis of Colorectal Cancer | |
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| Anti-Angiogenic Therapy by Interference with the VEGF Pathway in Colorectal Cancer | |
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| Vascular Endothelial Growth Factor in Malignant Disease of the Central Nervous System | |
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| VEGF in the Normal Brain | |
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| VEGF Is Upregulated in Malignant Disease of the CNS | |
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| Angiogenesis in Glioma | |
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| Factors Influencing VEGF Production | |
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| C6 Glioma Is an Excellent Model for the Study of High Grade Human Glioma with Regard to VEGF | |
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| VEGF Is Responsible for the Virulent Nature of High Grade Gliomas | |
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| Interrupting VEGF-Receptor Signaling Inhibits Glioma Growth in Preclinical Models | |
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| Current Therapy of Glioma: VEGF Contributes to Treatment Failure | |
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| VEGF in Hematopoietic Malignancy | |
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| The VEGF/VEGF Receptor Pathway | |
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| Hematopoietic and Endothelial Cells Share a Common Hematopoietic/Endothelial Progenitor Cell | |
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| VEGF Bone Marrow Interactions in Hematological Malignancy | |
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| VEGF and Angiogenesis in Acute Leukemia and Myelodysplasia | |
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| VEGF and Angiogenesis in Myeloproliferative Disorders | |
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| VEGF and Angiogenesis in B-Cell Chronic Lymphocytic Leukemia | |
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| VEGF and Angiogenesis in Lymphomas | |
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| VEGF and Angiogenesis in Myeloma | |
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| VEGF Signalling Pathways As a Therapeutic Target in Hematological Malignancies | |
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| Targeting VEGF in Pancreatic Cancer | |
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| Cancer Metastasis | |
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| Tumor Angiogenesis | |
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| Regulation of Angiogenesis by the Microenvironment | |
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| VEGF/VPF: A Pro-Angiogenic Molecule | |
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| Regulation of VEGF/VPF Expression in Tumors | |
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| Development of a Human Pancreatic Adenocarcinoma Model | |
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| Anti-VEGF Therapy in Pancreatic Cancer | |
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| Anti-Angiogenic Therapy: Clinical Implications | |
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| Effects of Fibrinogen and Associated Peptide Fragments on the Activation of Human Endothelial Cells by VEGF in Vitro | |
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| Fibrinogen and Fibrin Formation | |
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| Fibrinolysis | |
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| Effects of Fibrinogen on Endothelial Cell Activation | |
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| Fibrin, VEGF and Angiogenic Mechanisms | |
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| Stimulation of VEGF Induced Angiogenesis by Fibrin E-Fragment | |
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| Fibrinogen E-Fragment Inhibits VEGF Activation of Endothelial Cells | |
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| The Effects of Other Fibrinogen/Fibrin Related Fragment on VEGF-Activation of Endothelial Cells | |
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| Vascular Endothelial Growth Factor (VEGF) and Its Role in Non-Endothelial Cells: Autocrine Signalling by VEGF | |
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| VEGF in the Cardiovascular System | |
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| VEGF and the Central Nervous System (CNS) | |
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| VEGF and Its Role in Bone | |
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| VEGF in Hematopoietic Cells and Hematological Malignancies | |
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| VEGF Signalling in Hematopoietic Cells | |
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| Evidence for VEGF Autocrine Signalling in Solid Tumors | |
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| Autocrine VEGF Signalling in Breast Cancer | |
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| VEGF Stimulates Breast Cancer Invasion | |
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| VEGF Signalling in Tumor Cells | |
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| Anti-Angiogenic Therapy | |
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| Vascular Endothelial Growth Factor C and Vascular Endothelial Growth Factor D: Biology, Functions and Role in Cancer | |
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| Molecular Biology of VEGF-C and VEGF-D | |
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| VEGF-C and VEGF-D Signalling and Function | |
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| VEGF-C and VEGF-D in Human Malignancy | |
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| Potential Therapeutic Roles | |
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| Index | |