Quest for the Cure The Science and Stories Behind the Next Generation of Medicines

ISBN-10: 0231152124

ISBN-13: 9780231152129

Edition: 2011

List price: $27.95 Buy it from $1.49
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Description:

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we may be reaching the end of drug discovery to combat major diseases. In this engaging book, Brent Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century. Filled with absorbing stories of breakthroughs, the book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and describes cellular and molecular barriers thwarting scientists who use tools from traditional pharmaceutical research. Scientists such as Stockwell are now developing methods to combat these complexities& -technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules& -all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Curetells a thrilling story of science, persistence, and the quest underway to develop a new generation of cures.
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Book details

List price: $27.95
Copyright year: 2011
Publisher: Columbia University Press
Publication date: 5/17/2011
Binding: Hardcover
Pages: 284
Size: 6.00" wide x 8.75" long x 1.00" tall
Weight: 0.990
Language: English

List of Illustrations
Preface
Acknowledgments
Abbreviations
The Vanishing Cures
The Drug Discovery Crisis
A New Science of Molecules
The Birth of the First Cancer Drugs
A New Company Creating Drug Combinations
The Undruggable RAS Protein
The Druggable Genome
The Path to the Next Generation of Medicines
Peering Inside Proteins
The Nature of Interactions Between Proteins
From Protein-Protein Interactions to Personalized Medicines
A Revolution in Peptide Synthesis
A Vast Array of Drug Candidates
Moving Outside the Small Molecule Box
Acceleratingthe Arrival of Next-Generation Drugs
Notes
Glossary
Index
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