Introduction to Risk Calculation in Genetic Counseling

ISBN-10: 0195305272
ISBN-13: 9780195305272
Edition: 3rd 2006 (Revised)
Authors: Ian D. Young
List price: $51.00 Buy it from $38.78 Rent it from $22.02
This item qualifies for FREE shipping

*A minimum purchase of $35 is required. Shipping is provided via FedEx SmartPost® and FedEx Express Saver®. Average delivery time is 1 – 5 business days, but is not guaranteed in that timeframe. Also allow 1 - 2 days for processing. Free shipping is eligible only in the continental United States and excludes Hawaii, Alaska and Puerto Rico. FedEx service marks used by permission."Marketplace" orders are not eligible for free or discounted shipping.

30 day, 100% satisfaction guarantee

If an item you ordered from TextbookRush does not meet your expectations due to an error on our part, simply fill out a return request and then return it by mail within 30 days of ordering it for a full refund of item cost.

Learn more about our returns policy

Description: The process of genetic counseling involves many key components, such as taking a family genetic history, making a diagnosis, and providing communication and support to the family. Among these core processes is the mathematical calculation of the  More...

New Starting from $38.78
Rent Starting from $22.02
what's this?
Rush Rewards U
Members Receive:
coins
coins
You have reached 400 XP and carrot coins. That is the daily max!
You could win $10,000

Get an entry for every item you buy, rent, or sell.

Study Briefs

Limited time offer: Get the first one free! (?)

All the information you need in one place! Each Study Brief is a summary of one specific subject; facts, figures, and explanations to help you learn faster.

Add to cart
Study Briefs
Calculus 1 Online content $4.95 $1.99
Add to cart
Study Briefs
Algebra Online content $4.95 $1.99
Add to cart
Study Briefs
Introduction to Logic Online content $4.95 $1.99
Add to cart
Study Briefs
Business Math Formulas Online content $4.95 $1.99

Customers also bought

Loading
Loading
Loading
Loading
Loading
Loading
Loading
Loading
Loading
Loading

Book details

List price: $51.00
Edition: 3rd
Copyright year: 2006
Publisher: Oxford University Press, Incorporated
Publication date: 10/16/2006
Binding: Paperback
Pages: 256
Size: 6.00" wide x 9.00" long x 0.75" tall
Weight: 1.034

The process of genetic counseling involves many key components, such as taking a family genetic history, making a diagnosis, and providing communication and support to the family. Among these core processes is the mathematical calculation of the actual risk of a possible genetic disorder. For most physicians and counselors, the mathematics and statistics involved can be major challenge which is not always helped by complex computer programs or lengthy papers full of elaborate formulae. In this clear, reader-friendly guide, Ian Young addresses this problem and demonstrates how risk can be estimated for inherited disorders using a basic knowledge of the laws of probability and their application to clinical problems. The text employs a wealth of clearly explained examples and key points in order to guide the reader to an accurate assessment of the risk of genetic disease. It primarily will appeal to genetic counselors, geneticists, and all those involved in providing medical genetic services. In this new edition, Dr. Young has pruned redundancies and extensively updated the concepts in each of the 10 chapters, and he has included more working examples, a popular feature of the book.

Genetic Counseling and the Laws of Probability
Genetic Counseling and the Concept of Risk
The Laws of Probability
The Binomial Distribution
Bayes' Theorem
Case Scenario
Autosomal Dominant Inheritance
Reduced Penetrance
Disorders with Late Onset (Age-Dependent Penetrance)
Variable Expression
Parents Have Two Different Autosomal Dominant Disorders
Parents Have the Same Autosomal Dominant Disorder
Affected Siblings Born to Unaffected Parents
Anticipation
Autosomal Recessive Inheritance
Hardy-Weinberg Equilibrium
Risk to the Offspring of a Healthy Sibling
Risks to the Extended Family
Risks to the Offspring of an Affected Homozygote
Two Brothers Marry Two Sisters
Siblings with Different Autosomal Recessive Disorders
Allowing for Separate Mutations
Consanguinity
Direct Mutation Analysis and Multiple Alleles
Case Scenario
X-Linked Recessive Inheritance
The Prior Probability That a Female Is a Carrier of an X-Linked Recessive Disorder
The Probability That the Mother of an Isolated Case Is a Carrier
The Carrier Risks for Female Relatives of an Isolated Case
Different Mutation Rates in Males and Females
Biological Fitness Is Greater Than Zero
Case Scenario
The Use of Linked DNA Markers
Basic Principles of Genetic Linkage
Autosomal Dominant Inheritance
Autosomal Recessive Inheritance
X-Linked Recessive Inheritance
Using Information from Flanking Markers
Disorders with Late Onset
Parental Genotypes Not Known
Linkage Disequilibrium
Linkage Heterogeneity
Case Scenario
Germline Mosaicism
What is Germline Mosaicism?
A Simplified Model of Gametogenesis
Applying This Simple Model
Risk Estimates for Use in Counseling
Case Scenario 1
Case Scenario 2
Polygenic and Multifactorial Inheritance
Polygenic Inheritance and the Normal Distribution
The Liability/Threshold Model
General Principles in Counseling for Multifactorial Disorders
Computer Program for Risk Estimation
The Use of Susceptibility Loci
Cancer Genetics
Breast Cancer
Colorectal Cancer
Balanced Chromosome Rearrangements
Reciprocal Translocations
Robertsonian Translocations
Three-Way Translocations
Pericentric Inversions
Paracentric Inversions
Insertions
Rearrangements Involving an X Chromosome
Case Scenario
Other Mechanisms of Inheritance
X-Linked Dominant Inheritance
X-Linked Dominant Inheritance with Male Lethality
X-Linked Dominant Inheritance with Male Sparing
Metabolic Interference
Digenic Inheritance
Uniparental Disomy and Imprinting
Somatic Crossing-Over
Meiotic Drive
Mitochondrial Inheritance
References
Appendices
Ultrasound and Prenatal Diagnosis
Overlapping Normal Distributions
Length of Prometaphase Chromosome Segments
Index

×
Free shipping on orders over $35*

*A minimum purchase of $35 is required. Shipping is provided via FedEx SmartPost® and FedEx Express Saver®. Average delivery time is 1 – 5 business days, but is not guaranteed in that timeframe. Also allow 1 - 2 days for processing. Free shipping is eligible only in the continental United States and excludes Hawaii, Alaska and Puerto Rico. FedEx service marks used by permission."Marketplace" orders are not eligible for free or discounted shipping.

Learn more about the TextbookRush Marketplace.

×