Molecular Evolution and Phylogenetics

ISBN-10: 0195135857

ISBN-13: 9780195135855

Edition: 2000

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Description: This book presents the statistical methods that are useful in the study of molecular evolution and illustrates how to use them in actual data analysis. Molecular evolution has been developing at a great pace over the past decade or so, driven by the huge increase in genetic sequence data from many organisms, the improvement of high-speed microcomputers, and the development of several new methods for phylogenetic analysis. This book for graduate students and researchers, assuming abasic knowledge of evolution, molecular biology, and elementary statistics, should make it possible for many investigators to incorporate refined statistical analysis of large-scale data in their own work. Nei is one of the leading workers in this area. He and Kumar have developed a computer programcalled MEGA, which has been sold for about $20 to over 1900 users. For the book, the authors are thoroughly revising MEGA and will make it available via FTP. The book also included analysis using the other most popular programs for phylogenetic studies, including PAUP, PHYLIP, MOLPHY, and PAML.

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Book details

List price: $83.00
Copyright year: 2000
Publisher: Oxford University Press, Incorporated
Publication date: 7/27/2000
Binding: Paperback
Pages: 352
Size: 7.25" wide x 9.75" long x 0.75" tall
Weight: 1.584
Language: English

Shagun Mehrotra is currently pursuing doctoral studies at Columbia University, New York. He has done research on infrastructure, economic development, and urban poverty in South-East Asia, China, and India. He has worked with the World Bank, and his advice has been sought for the UnitedNations Human Development Report (2006) and the Bill and Melinda Gates Foundation, among others. Sudhir Kumar, IAS, is Officer on Special Duty to the Minister of Railways. Kumar's most significant contribution in the recent transformation of the railways is his pioneering work in assisting theMinister in crafting a reform strategy for the railways that does not burden the poor consumers. A student of Delhi School of Economics, he belongs to the 1982 Bihar cadre.

Numerical Examples
Molecular Basis of Evolution
Evolutionary Change of Amino Acid Sequences
Evolutionary Change in DNA Sequences
Synonymous and Nonsynonymous Nucleotide Substitutions
Phylogenetic Trees
Phylogenetic Inference: Distance Methods
Phylogenetic Inference: Maximum Parsimony Methods
Phylogenetic Inference: Maximum Likelihood Methods
Accuracies and Statistical Tests of Phylogenetic Trees
Molecular Clocks and Linearized Trees
Ancestral Nucleotide and Amino Acid Sequences
Genetic Polymorphism and Evolution
Population Trees from Genetic Markers
Perspectives
Appendices
References
Index
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