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| Physiochemical Principles of Drug Action | |
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| Role and Structure of Water | |
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| Solubility | |
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| Partition Coefficients | |
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| Surface Activity and Drug Effects | |
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| Stereochemical Aspects of Drug Action | |
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| Electronic Structure and its Effects on Drug Activity | |
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| Chemical Bonding and Biological Activity | |
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| Quantum Chemical Aspects of Drug Action | |
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| Quantitative Structure-Activity Relationships | |
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| Receptor-Effector Theories | |
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| The Receptor Concept and its History | |
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| The Nature of Receptors and the Criteria of Receptor Identity | |
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| Definition of Pharmacological Binding Terms | |
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| Classical Theories of Concentration-Response Relationships | |
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| Molecular Concepts of Receptor function | |
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| Methods of Receptor Characterization | |
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| Methodological Principles | |
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| Indirect Methods of Receptor Characterization | |
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| Direct Methods of Receptor Characterization | |
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| Data Treatment | |
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| Drugs Acting on Neurotransmitters and Their Receptors | |
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| Outline of Neuroanatomy and Neurophysiology | |
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| Acetylcholine and the Cholinergic Receptors | |
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| Norepinephrine and the Adrenergic Receptors | |
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| Dopamine and the Dopaminergic Receptors | |
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| Serotonin and the Serotonergic Drug Effects | |
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| Histamine and the Histamine Receptors | |
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| Purinergic Neuromodulation and the Adenosine Receptors | |
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| Aminoacid Neurotransmitters and the Drug Effects They Mediate | |
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| Drugs Acting on Hormones, Neurohormones, and Their Receptors | |
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| Steroid Hormones and Their Receptors | |
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| Peptide and Protein Hormones and Neurohormones | |
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| Enkephalins, Endorphins, and Opiate Analgesics | |
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| Prostaglandins and Thromboxanes | |
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| Atrial Natriuretic Factors | |
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| Non-Messenger Targets for Drug Action | |
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| Excitable Membranes | |
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| Cell-Wall Synthesis Inhibitors | |
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| Enzymes as Drug Targets | |
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| Vitamins | |
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| Nucleic Acids as Targets for Drug Action | |
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| Drug Distribution and Metabolism | |
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| Drug Distribution | |
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| Drug Metabolism | |
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| Principles of Drug Design | |
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| Analogue Synthesis Versus Rational Design | |
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| Discovery of "Lead" Compounds | |
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| Pharmacophore Identification | |
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| Pro-Drugs and "Soft" Drugs | |