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Development of the Nervous System

ISBN-10: 0126186219
ISBN-13: 9780126186215
Edition: 2nd 2005 (Revised)
List price: $97.95
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Description: Development of the Nervous System, Second Edition has been thoroughly revised and updated since the publication of the first edition. It presents a broad outline of neural development principles as exemplified by key experiments and observations  More...

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Book details

List price: $97.95
Edition: 2nd
Copyright year: 2005
Publisher: Elsevier Science & Technology Books
Publication date: 10/6/2005
Binding: Hardcover
Pages: 392
Size: 8.75" wide x 11.50" long x 1.00" tall
Weight: 3.036

Development of the Nervous System, Second Edition has been thoroughly revised and updated since the publication of the first edition. It presents a broad outline of neural development principles as exemplified by key experiments and observations from past and present times. The text is organized along a development pathway from the induction of the neural primordium to the emergence of behavior. It covers all the major topics including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, synapse formation and plasticity, and neuronal survival and death. This new text reflects the complete modernization of the field achieved through the use of model organisms and the intensive application of molecular and genetic approaches. The original, artist-rendered drawings from the first edition have all been redone and colorized to so that the entire text is in full color. An accompanying CD-ROM contains all of the images from the book, ideal for slides, handouts, and presentations. This new edition is an excellent textbook for undergraduate and graduate level students in courses such as Neuroscience, Medicine, Psychology, Biochemistry, Pharmacology, and Developmental Biology. * Updates information including all the new developments made in the field since the first edition * Now in full color throughout, with the original, artist-rendered drawings from the first edition completely redone, revised, colorized, and updated * Includes a CD-ROM with all of the images from the book

Preface
Induction
Development and Evolution of Neurons
Early Embryology of Metazoans
Neural Tissue Is Derived from Ectoderm
Interactions with Neighboring Tissues Are Required for the Ectoderm to Make Neural Tissue in Many Animals
Interactions among the Ectodermal Cells Control Neuroblast Segregation
Polarity and Regionalization
Regional Identity of the Nervous System
The Anterior--Posterior Axis and Hox Genes
Hox Gene Function
Signaling Molecules that Pattern the Anterior--Posterior Axis in Vertebrates
Organizing Centers in the Developing Brain
Forebrain Development, Prosomeres, and Pax Genes
Dorsal--Ventral Polarity in the Neural Tube
Molecular Basis of Dorsal--Ventral Polarity
Dorsal Neural Tube and Neural Crest
Birth and Migration
Cell Cycle Genes Control the Number of Neurons Generated during Development
Cell Interactions Control the Number of Neurons and Glia Generated
Cerebral Cortex Histogenesis
The Subventricular Zone: A Secondary Zone of Neurogenesis
Cerebellar Cortex Histogenesis
Postembryonic and Adult Neurogenesis
Determination and Differentiation
Transcriptional Control of Invariant Lineages
Position and Determination
Multiple Interactions in a Lineage-Based System with Asymmetric Cell Division
The Dominance of Cellular Interactions in the Determination of Drosophila Retinal Cells
Vertebrate Retinogenesis Has a Similar Developmental Strategy
Glial Cell Fate
Fate Decisions in the Vertebrate Neural Crest
Neuronal Fate in the Vertebrate Spinal Cord
Laminar Fate in the Cerebral Cortex
Positional Cues Determine Axonal Projection Patterns
Regulation of Phenotype by the Target
Conclusions
Axon Growth and Guidance
Axonal Navigation
The Growth Cone
The Growing Zone
The Dynamic Cytoskeleton
Growth Cone Guidance
Mechanical Guidance
Adhesive Guidance
Extracellular Matrix and Axon Outgrowth
Cell Adhesion Molecules
Labeled Pathways and Global Guidance
Gradients of Diffusible Tropic Factors
Repulsive Factors
Axon Regeneration
Stop Factors
Signal Transduction
Summary
Target Selection
Cellular Target Recognition
Multicellular Targets
Secondary Targets
Targeting to the Correct Layer
Topographic Mapping
Mapping the Body
Somatotopy: Maps in the Brain and Their Modification
Visual Maps and the Theory of Chemospecificity
Determination of Retinotopic Identity
Shifting Connections, Fine Tuning, and Registration
Olfactory Maps
Computational Maps
Summary
Survival and Growth
What Does Neuron Death Look Like?
How Many Neurons Die?
Survival Depends on the Synaptic Target
NGF: A Target-Derived Survival Factor
NGF Is a Member of the Neurotrophin Family
There Is a Family of Neurotrophin Receptors
The Low-Affinity Neurotrophin Receptor
The Expanding World of Survival Factors
Endocrine Control of Cell Survival
Cell Death Requires Protein Synthesis
Intracellular Signaling
Caspases: Agents of Death
Regulating Death Proteins
Synaptic Transmission at the Target
Afferent Regulation of Cell Survival
Summary
Synapse Formation and Electric Function
Synaptogenesis
What Does Synapse Formation Look Like?
Where Do Synaptic Specializations Form?
Initial Signs of Synaptogenesis in Vitro
Role of Calcium during Presynaptic Differentiation
Second Messengers Mediate Presynaptic Differentiation
Molecular Signals and Presynaptic Differentiation
Receptor Clustering Signifies Postsynaptic Differentiation at NMI
Presynaptic Terminals Induce Receptor Aggregation
Agrin, a Transynaptic Clustering Signal
Postsynaptic Response to Agrin
Receptor Clustering Mechanisms in the CNS
Regulation of Receptor Expression and Synthesis
Neuronal Activity Limits Receptor Expression
ARIA, a Transynaptic Regulator of Transcription
Synaptic Transmission
Rapid Modulation of Release and Receptor Function
Maturation of Transmission and Receptor Isoform Transitions
Maturation of Transmitter Reuptake
Appearance of Synaptic Inhibition
Is Inhibition Really Inhibitory during Development?
Electrical Properties
Resting Potential and Membrane Properties
The Action Potential
Channel Diversity
Significance of Calcium Channel Expression
Regulation of Ionic Channel Expression
Summary
Refinement of Synaptic Connections
Rearranging Synaptic Connections
Functional Synapses Are Eliminated
Axonal Arbors Are Refined or Eliminated
Some Terminals Expand or Remain Stable
Neural Activity Regulates Synaptic Connections
Sensory Coding Properties Reflect Synapse Rearrangement
Activity Contributes to the Alignment of Sensory Maps
Spontaneous Activity and Afferent Segregation
Some Forms of Plasticity Have a Time Limit
Cellular Events during Synapse Elimination
Synapses Interact over a Short Distance
Effect of Disuse
Heterosynaptic Depression
Postsynaptic Receptors Are Eliminated
Involvement of Intracellular Calcium
NMDA Receptors and Calcium Signaling
The Role of Second Messenger Systems
Metabotropic Receptors: The Plot Broadens
Gain Control
Silent Synapses
Plasticity of Inhibitory Connections
Synaptic Influence on Neuron Morphology
Conclusions
Behavioral Development
Behavioral Ontogeny
Cellular and Environmental Mechanisms
Environmental Determinants of Behavioral Development
Motor Behavior: The First Movements
Are the First Behaviors Spontaneous or Reflexive?
The Mechanism of Spontaneous Movements
Embryonic Movements: Uncoordinated or Integrated?
The Role of Activity in the Emergence of Coordinated Behavior
Embryo-Specific Behaviors
Motor Learning
Beginning to Make Sense of the World
Asking Babies Questions
Sharp Eyesight
Acute Hearing
Sex-Specific Behavior
Genetic Sex
Hormonal Signals
Hormonal Control of Brain Gender
Genetic Control of Brain Gender
Singing in the Brain
From Gonads to Brain?
Learning to Remember
Where's Mamma?
Fear and Loathing
Complex Tasks
Getting Information from One Brain to Another
Language
Summary
References
Index

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