Organic Chemistry of Drug Design and Drug Action

ISBN-10: 0123820308

ISBN-13: 9780123820303

Edition: 3rd 2014

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Description:

Standard medicinal chemistry courses and textbooks are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This textbook represents a novel and unique approach based on physical organic chemical principles and reaction mechanisms that rationalize drug action and allow the reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. The Third Edition reflects significant changes in the drug industry and the process of drug design over the past decade. The Third Edition will preserve the successful approach of the current edition with significant changes in format and coverage to make the Third Edition even more appealing to users of the Second Edition as well as to users of competitive titles. Organic chemist's perspective of how drugs are discovered and designed.Focus on drug function at the molecular level. Use of clinically important drugs by commercial name and by generic name as examples. Inquiry methodology: text poses problems to the reader, some of which are solved, some of which require more analysis.Flexibility for use as a professional reference.
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Book details

List price: $60.99
Edition: 3rd
Copyright year: 2014
Publisher: Elsevier Science & Technology
Publication date: 5/21/2014
Binding: Hardcover
Pages: 536
Size: 9.00" wide x 11.25" long x 1.25" tall
Weight: 3.806
Language: English

Dr. Mark W. Holladay is Vice President of Drug Discovery and Medicinal Chemistry at Ambit Biosciences (San Diego, California) where he leads drug discovery programs in oncology and autoimmune diseases and has contributed to compounds in clinical development. He began his drug hunting career at Abbott Laboratories where he achieved the position of Volwiler Associate Research Fellow as a medicinal chemist and project leader in the Neurosciences Research Area. He also conducted collaborative drug discovery research as a member of contract research organizations including Biofocus and Discovery Partners International. He is a co-author on over 70 peer-reviewed research articles, reviews, or chapters and is named as an inventor on over 40 patents and patent applications. Dr. Holladay earned his undergraduate degree from Vanderbilt University, his Ph.D. at Northwestern University under the direction of Professor Richard B. Silverman, and conducted postdoctoral studies with Professor Daniel H. Rich at the University of Wisconsin-Madison.

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