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| Contributors | |
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| Preface | |
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| How to Make a Heart: The Origin and Regulation of Cardiac Progenitor Cells | |
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| Introduction | |
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| The Origin of the Heart Fields and Cardiac Progenitor Cell Behavior | |
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| Markers of Cardiac Progenitors and the Distinction Between First and Second Heart Fields (FHF and SHF) | |
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| Cardiac Progenitor Contributions to the Cell Types of the Heart | |
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| Subdomains of the SHF | |
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| Molecular Mechanisms that Govern SHF Cell Behavior-Transcriptional Regulators and Signaling Pathways | |
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| Conclusion | |
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| Acknowledgments | |
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| References | |
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| Vascular Development-Genetic Mechanisms and Links to Vascular Disease | |
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| Introduction | |
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| VEGF in Vascular Development | |
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| BMP in Vascular Development | |
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| Notch/Delta/Jagged in Vascular Development | |
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| Perspectives | |
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| Acknowledgments | |
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| References | |
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| Lung Organogenesis | |
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| Introduction | |
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| Developmental Anatomy of the Lung | |
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| Molecular Embryology of the Lung | |
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| Mechannbiology of the Developing Lung | |
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| Stem/Progenitor Cell Biology of the Lung | |
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| Postnatal and Adult Lung | |
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| Conclusions | |
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| Acknowledgments | |
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| References | |
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| Transcriptional Networks and Signaling Pathways that Govern Vertebrate Intestinal Development | |
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| Introduction | |
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| Formation of the Definitive Endoderm | |
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| The Formation and Regionalization of the Primitive Gut Tube | |
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| Establishment of the Crypt-Villus Axis | |
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| Establishing the Stem Cell Niche and Homeostasis in the Intestinal Epithelium | |
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| Role of Intestinal Development Pathways in Cancer | |
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| Acknowledgments | |
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| References | |
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| Kidney Development: Two Tales of Tubulogenesis | |
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| Introduction: How You Get a Kidney | |
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| The First Tale of Tubulogenesis: a Branching Tree | |
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| Tubulogenesis Via MET-Tube One Induces Tube Two | |
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| Patterning the Resulting Tubules | |
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| Moving From Structure to a Functional Filter | |
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| Disruptions to Kidney Tubulogenesis in Human Disease | |
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| Conclusion | |
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| Acknowledgments | |
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| References | |
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| The Game Plan: Cellular and Molecular Mechanisms of Mammalian Testis Development | |
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| Introduction | |
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| Introducing the Players: Cell Biology and Morphology of the Gonads | |
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| Origin of Sertoli Cells | |
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| Kirkoff in Testis Determination: Sty and Sertoli Cell Specification | |
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| The Goalkeeper: Sox9 and Sertoli Cell Differentiation | |
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| Forward Players: Beyond Sox9 | |
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| The Sweepers: Peritubular Myoid Cells | |
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| Interplay Between PM and Other Testicular Cells | |
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| The Midfielders: Leydig Cells | |
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| The White Lines: Endothelial Cells | |
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| What All the Fuss Is About: Germ Cells | |
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| Concluding Remarks | |
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| Acknowledgments | |
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| References | |
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| Building Pathways for Ovary Organogenesis in the Mouse Embryo | |
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| Evolution of the Hypotheses for Ovary Organogenesis in Mammals | |
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| Building the Foundation: Morphogenesis of the Ovary | |
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| Making Eggs: Establishment of the Female Germline | |
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| Determination of the Ovarian Identity: Differentiation of Granulosa Cells | |
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| Emerging Pathways for the Establishment of Female Somatic Environment and Maintenance of Female Germ Cells | |
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| Conclusion and Perspectives | |
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| References | |
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| Vertebrate Skeletogenesis | |
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| Introduction | |
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| Structural Organization and Advantages of the Vertebrate Skeleton | |
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| Development of Skeletogenic Cells | |
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| Development of Cartilage Anlagen | |
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| Development of Cartilage Growth Plates | |
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| Bone Development | |
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| Synovial Joint Formation | |
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| Skeleton Variation | |
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| Perspectives | |
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| Acknowledgments | |
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| References | |
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| The Molecular Regulation of Vertebrate Limb Patterning | |
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| Introduction | |
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| The Early Limb | |
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| Patterning Along the AP Axis | |
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| Proximal-Distal Patterning and Outgrowth | |
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| Interaction Between the ZPA and the AER | |
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| Towards a Systems Biology Approach to Limb Patterning | |
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| Acknowledgments | |
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| References | |
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| Eye Development | |
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| Introduction | |
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| Overview of Eye Development | |
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| Early Stage: The Eye Field | |
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| Lens Development | |
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| The Cornea | |
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| The Iris and the Ciliary Body | |
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| The Retina | |
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| The Optic Nerve | |
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| Conclusion and Perspectives | |
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| Acknowledgments | |
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| References | |
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| Index | |
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| Contents of Previous Volumes | |