Research Methodology in the Medical and Biological Sciences

ISBN-10: 0123738741

ISBN-13: 9780123738745

Edition: 2007

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Description:

Providing easy-to-access information, this unique sourcebook covers the wide range of topics that a researcher must be familiar with in order to become a successful experimental scientist. Perfect for aspiring as well as practicing professionals in the medical and biological sciences it discusses a broad range of topics that are common, yet not traditionally considered part of formal curricula. The information presented also facilitates communication across conventional disciplinary boundaries, in line with the increasingly multidisciplinary nature of modern research projects. Perfect for students with various professional backgrounds providing a broad scientific perspective Easily accessible, concise material makes learning about diverse methods achievable in todays fast-paced world Extensive online resources include further reading suggestions, data files, statistical tables, and the StaTable application package
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Book details

List price: $54.95
Copyright year: 2007
Publisher: Elsevier Science & Technology Books
Publication date: 11/5/2007
Binding: Paperback
Pages: 512
Size: 6.00" wide x 9.00" long x 1.00" tall
Weight: 1.584
Language: English

Preface
Contributors
List of abbreviations and symbols
Philosophy of Science
Philosophy of the natural sciences
Philosophy of the social sciences
Ethics and Scientific Conduct
A brief introduction to ethics
Scientific conduct and misconduct
Misconduct and why it occurs
Fabrication and other forms of misconduct affecting the truth claims of scientific findings
Authorship issues
Salami, imalas and duplicate publication
The investigation and punishment of scientific misconduct
Ethics in Human and Animal Studies
Introduction
Basic principles of human research ethics
International regulation
The ethics of animal research
World (Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects
Oviedo Convention (Council of Europe, European Treaty Series 164)
Oviedo Convention-Additional Protocol Concerning Biomedical Research, Chapter I-IX (Council of Europe, European Treaty Series 195)
Research Methodology: Strategies, Planning and Analysis
Introduction
Your scientific problem
More on scientific problems
Literature, methods and techniques
Research conditions
Data types
Techniques
Repeatability, reproducibility and reliability
Validity, effect measure and choice of statistical test
Experimental protocol
Experimental routine
Literature Search and Personal Reference Databases
Information literacy
Systematic literature search
How to formulate a query: PICO
Search technique
Methodology filters
Quality: critical appraisal
Impact factor
Principal bibliographic databases
Staying up to date
Medical and scientific internet search engines
Personal reference databases
Methods in Molecular Biology
Introduction
Recombinant DNA technology
DNA and RNA: isolation, identification, synthesis and analysis
Practical applications of DNA/RNA technology
Protein analyses
Bioinformatics
Strategies and Methods of Basic Medical Research
Introduction
Long-term goals and specific aims
Background and significance
Experimental strategies and methods
Pilot studies
Rules for basic medical research projects
Clinical Research
Controlled clinical trials
Publication bias
Estimating sample size
'Non-inferiority' studies
Generalization
Epidemiology: Concepts and Methods
Introduction
Definitions
The role of epidemiology
Population and sample
Measures of disease occurrence, association, risk and implications
Vital statistics
Study designs of epidemiological studies
Effect measures in epidemiological studies
Experimental studies and randomized control trials
Measurement error and sources of error
Tests and validity
Causes of disease
Association versus causality
Qualitative Research
Qualitative versus quantitative research
Using qualitative research
What qualitative research cannot be used for
Samples in qualitative studies
Reliability and validity
Ethical challenges in qualitative research
Qualitative data collection
Triangulation
Analyses of qualitative data
Releasing qualitative data
Statistical Issues
Introduction
Effect measure, hypothesis testing and confidence interval
Bernoulli trial
Comparing two proportions
Measures of association in 2 x 2 tables
Normal distribution
Comparison of means
Non-parametric methods
Regression analysis
Evidence-Based Practice and Critical Appraisal of Systematic Reviews
Introduction
Systematic reviews
Critical appraisal of a systematic review: one example
Summary
Scientific Communication
Introduction
The scientific paper
Posters
Successful Lecturing
Introduction
Preparing the lecture
Lecture content and form
Manuscript
Delivering a lecture
Guide to Grant Applications
Introduction
Getting started
The postdoctoral fellow and junior scientist
What goes into a successful grant application?
The investigator-initiated research grant
Multiproject grants
International research collaborations
The European Union's seventh Framework Programme
Summary and perspective
Index
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