Forensic DNA Typing Biology, Technology, and Genetics of STR Markers

ISBN-10: 0121479528
ISBN-13: 9780121479527
Edition: 2nd 2005 (Revised)
Authors: John M. Butler
List price: $96.95
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Description: Since the enormously successful first edition of Forensic DNA Typing was published, the Human Genome Project has published a draft sequence of the human genome and completed the finished reference sequence. The advent of modern DNA technology has  More...

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Book details

List price: $96.95
Edition: 2nd
Copyright year: 2005
Publisher: Elsevier Science & Technology Books
Publication date: 2/22/2005
Binding: Hardcover
Pages: 688
Size: 7.44" wide x 9.69" long x 2.00" tall
Weight: 2.442
Language: English

Since the enormously successful first edition of Forensic DNA Typing was published, the Human Genome Project has published a draft sequence of the human genome and completed the finished reference sequence. The advent of modern DNA technology has resulted in the increased ability to perform human identity testingdesirable in a number of situations including the determination of perpetrators of violent crime such as murder and rape, resolving unestablished paternity, and identifying remains of missing persons or victims of mass disasters. The technology has been utilized in identifying remains from victims of the World Trade Center twin towers collapse following the terrorist attacks of September 11, 2001, the President Clinton-Monica Lewinsky scandal, and the identification of the remains in the Tomb of the Unknown Soldier. Indeed, our perceptions of history have been changed with DNA evidence that revealed Thomas Jefferson fathered a child by one of his slaves. This book examines the science of current forensic DNA typing methods by focusing on the biology, technology, and genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century.

John M. Butler is a NIST Fellow and Group Leader at the U.S. National Institute of Standards and Technology, Gaithersburg, Maryland. Dr. Butler earned his PhD from the University of Virginia while doing DNA research in the FBI Laboratory's Forensic Science Research Unit. He has over 100 publications in this field and is a frequent presenter on the topic of DNA typing.

Overview and history of DNA typing
DNA biology review
Sample collection, DNA extraction and DNA quantitation
The polymerase chain reaction (DNA amplification)
Commonly used short tandem repeat markers and commercial kits
Biology of STRs : stutter products, non-template addition, microvariants, null alleles and mutation rates
Forensic issues : degraded DNA, PCR inhibition, contamination, mixed samples and low copy number
Single nucleotide polymorphisms and other bi-allelic markers
Y chromosome DNA testing
Mitochondrial DNA analysis
Non-human DNA testing and microbial forensics
DNA separation methods : slab gel and capillary electrophoresis
DNA detection methods : fluorescent dyes and silver-staining
Instrumentation for STR typing : ABI 310, ABI 3100, FMBIO systems
STR genotyping issues
Laboratory validation
New technologies, automation, and expert systems
Combined DNA index system (CODIS) and the use of DNA databases
Basic genetic principles, statistics, and probability
STR population database analyses
Profile frequency estimates, likelihood ratios, and source attribution
Approaches to statistical analysis of mixtures and degraded DNA
Kinship and parentage testing
Mass disaster DNA victim identification
Reported STR alleles : sizes and sequences
U.S. population data - STR allele frequencies
Suppliers of DNA analysis equipment, products, OR services
DNA advisory board quality assurance standards
DAB recommendations on statistics
NRC II recommendations
Example DNA cases

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