Comprehensive Toxicology, Volume 1 General Principles

Name: Comprehensive Toxicology, Volume 1 General Principles
Availability: OutOfStock
ISBN: 9780080429663

ISBN-10: 0080429661

ISBN-13: 9780080429663

Edition: 1997

Authors: J. A. Bond

List price: $260.00

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Description:

Volume 1 provides the reader with a basic overview of the field of toxicology. The volume is divided into four sections: 1) introduction, 2) toxicokinetics, 3) mechanisms of toxicity, and 4) risk assessment. The volume provides an in-depth coverage of the field of toxicokinetics including exposure assessment, routes of exposure of toxicants, and distribution, biotransformation, and excretion of toxicant. Dosimetry modeling, including physiologically based pharmacokinetic models, and extrapolation modeling are covered. The volume also covers key mechanisms associated with toxicity/carcinogenicity of chemicals. Concepts of risk assessment are also discussed in this volume. The contents of…

Book details

List price: $260.00
Copyright year: 1997
Publisher: Elsevier Science & Technology
Publication date: 8/4/1999
Binding: Hardcover
Pages: 354
Size: 7.50" wide x 10.75" long x 1.00" tall
Weight: 2.398
Language: English



Introduction to the principles of toxicology



Exposure analysis and its assessment



Toxicokinetics: oral exposure and absorption of toxicants



Toxicokinetics: inhalation exposure and absorption of toxicants



Toxicokinetics: dermal exposure and absorption of toxicants



Toxicokinetics: distribution of toxicants



Toxicokinetics: biotransformation of toxicants



Toxicokinetics: routes of elimination



Toxicokinetics: concepts of dose



Toxicokinetics: modeling disposition



Toxicologic interactions of chemical mixtures



Experimental models for the investigation of toxicological mechanisms



Cytolethality: necrosis vs. apoptosis



Mitogenesis



The calcium messenger system



Mechanisms: free radicals and reactive oxygen species



DNA-reactive agents



Risk assessment