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Deciphering the Role of Yap4 Phosphorylation under Stress Conditions

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ISBN-10: 3845417609

ISBN-13: 9783845417608

Edition: N/A

Authors: Jorge Pereira

List price: $64.00
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Yap4 is a phosphoprotein highly induced upon the different stress conditions previously shown to increase the transcription of its gene (osmotic and oxidative stress, heat, arsenate exposure, etc) as well as during stationary phase. Yap4 is downstream the HOG Pathway and the General Stress Response and its phosphorylation is PKA-dependent. Mutation of Yap4 residues T192 and S196 abolishes its phosphorylation, but not its nuclear localization or ability to partially rescue the hog1 severe osmosensitivity phenotype. Phosphorylation seems, however, to affect Yap4 stability as the non-phosphorylated form has a shorter half-life compared to the phosphorylated one. Removal of Yap4 leucine zipper…    
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Book details

List price: $64.00
Publisher: Lap Lambert Academic Publishing GmbH & Company KG
Binding: Paperback
Pages: 208
Size: 6.00" wide x 9.00" long x 0.48" tall
Weight: 0.682
Language: English