Human Stat1 Deficiencies

Name: Human Stat1 Deficiencies
Price: 58.97 USD
Availability: InStock
ISBN: 9783844301687

ISBN-10: 3844301682

ISBN-13: 9783844301687

Edition: N/A

Authors: Ariane Chapgier

List price: $80.00

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Description:

The Signal Transducer and Activator of Transcription 1 (STAT1) is activated in response to interferons (IFNs) stimulations. In response to IFN- , STAT1 homodimerizes to form the gamma activating factor (GAF). In response to IFN- , STAT1 heterotrimerizes with STAT2 and ISGF3- to form the interferon sequence gene factor 3 (ISGF3). This work clearly demonstrates the distinct roles of the IFN- -induced-GAF complexes in anti-mycobacterial immunity and of IFN- induced- ISGF3 complexes in the anti-viral immunity in humans at the cellular and clinical levels by different molecular mechanisms. It also highlights the fact that a phenotype depends of the mutation and not only of the affected gene; and…

Book details

List price: $80.00
Publisher: Lap Lambert Academic Publishing GmbH & Company KG
Binding: Paperback
Pages: 136
Size: 6.00" wide x 9.00" long x 0.32" tall
Weight: 0.462
Language: English