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Biochemical Characterization of Dystrophin Spectrin Type Repeats

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ISBN-10: 3843360812

ISBN-13: 9783843360814

Edition: N/A

Authors: Ismaeel Muhamed

List price: $67.00
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Description:

The dystrophin gene and its association with dystrophies is a prime factor to study the spectrin type repeats (STR) of dystrophin. There are 24 triple helical rods of Dystrophin STRs having four flexible hinges. The exon skipping and tissue specifity of the dystrophin isoforms make its function diverse. The deletion of STRs and mutations causes instability of the protein leading to diseases. This work studies the stability of spectrin type repeat, which would identify the roles and probably understand the function of individual spectrin repeat in diseases. The repeats are subjected to urea and temperature and the helical stability is measured. Structure prediction methods were worked on…    
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Book details

List price: $67.00
Publisher: Lambert Academic Publishing
Binding: Paperback
Pages: 76
Size: 6.00" wide x 9.00" long x 0.18" tall
Weight: 0.286
Language: English