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Complement and Cd14 Roles in Escherichia coli-induced Inflammation

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ISBN-10: 3838373804

ISBN-13: 9783838373805

Edition: N/A

Authors: Ebbe Billmann Thorgersen

List price: $72.00
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Description:

Sepsis is a systemic inflammatory response syndrome caused by infection. A range of biomarkers have been shown to correlate with disease activity and death in sepsis. However, targeting single downstream mediators in clinical sepsis trials, like the central proinflammatory cytokine TNF- , have been disappointing. A better approach may be inhibition of upstream inducers instead of downstream mediators of inflammation. The aims of this study were to find effective inhibitors of complement and CD14/TLR4/MD2, two key upstream innate immunity inducers of inflammation The studies were conducted in vitro and in vivo in a pig model. The pig is a well suited animal for studying human diseases. The…    
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Book details

List price: $72.00
Publisher: Lap Lambert Academic Publishing GmbH & Company KG
Binding: Paperback
Pages: 124
Size: 6.00" wide x 9.00" long x 0.29" tall
Weight: 0.440
Language: English