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Philadelphia Chromosome A Mutant Gene and the Quest to Cure Cancer at the Genetic Level

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ISBN-10: 1615190678

ISBN-13: 9781615190676

Edition: 2013

Authors: Jessica Wapner, Robert A. Weinberg

List price: $38.95
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Description:

Almost daily, headlines announce newly discovered links between cancers and their genetic causes. The Philadelphia Chromosome relates the backstory—never before told at book length—behind many of those headlines. This epic journey unfolds over fifty years, encompassing the first glimpse of a genetic mutation, dubbed the Philadelphia chromosome, in 1959; its role in causing chronic myeloid leukemia (CML); and the development of Gleevec, a groundbreaking drug that made this once-fatal cancer treatable with a single daily pill.Science journalist Jessica Wapner brings this story vividly to life—reconstructing the crucial breakthroughs, explaining the science behind them, and giving due to the…    
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Book details

List price: $38.95
Copyright year: 2013
Publisher: Experiment LLC, The
Publication date: 5/14/2013
Binding: Hardcover
Pages: 320
Size: 6.25" wide x 9.25" long x 1.00" tall
Weight: 1.232

Jessica Wapner is a freelance writer focused mainly on healthcare and medicine. Her work is published in The New York Times , Scientific American , Slate , Science , Nature Medicine , Ode , and Psychology Today . Her writing on cancer research and treatment also appears in the science magazines Oncology Business Review, Cure , and CR . Her blog, Work in Progress, is part of the PLoS Blog Network and focuses on the ethics and economics of drug development. She was the founding managing editor of two review journals, Clinical Advances in Hematology & Oncology and Gastroenterology & Hepatology , and also served as editor for Oncology Spectrum . She lives in Beacon, New York, with her husband…    

Author's Note
Foreword
Prelude: Down to the Bone, February 2012
The Chromosome and the Disease, 1959-1990
The First Clue
Three Hundred Words
Investigating a Chicken Virus
Right Number, Wrong Place
The Surprising Source of the Chicken Cancer Gene
Consummate Instigators
Where the Kinase Hangs the Keys
A Chemical Amputation
Stripping Away the Fur and the Fat
A Funny New Protein
The First Sign of a Human Cancer Gene
Spelling Out the Translocation
"That Word Is Oncogenes"
Rational Design, 1983-1998
Becoming a Doctor, and Then a Scientist
Turning a Protein into a Drug Target
A Machine with a Virus for a Motor
Plucking the Low-Hanging Fruit
A Drug in Search of a Disease
Two Endings
Getting Out of Boston
Killing Cells
Gain and Loss
"Not Over My Dead Body Will This Compound Go into Man"
Human Trials, 1998-2001
The Quickest Answer
Getting to 200 Milligrams
The One Thing They Didn't Have
Buzz in the Chat Rooms
Saving Their Own Lives
A Response Rate of One Hundred Percent
Good Stressful
Putting It in Writing
A Truck load of Data
The Fathers of Victory
Aftermath
A Price to Pay
Showing a Weakness
The First Five Years
The Second Generation
A Gleevec for Every Cancer
Epilogue: Survival Time
Glossary
References
Acknowledgments
Index
Photo Credits
About the Author