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Sample Size Calculations in Clinical Research

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ISBN-10: 1584889829

ISBN-13: 9781584889823

Edition: 2nd 2007 (Revised)

Authors: Shein-Chung Chow, Hansheng Wang, Jun Shao

List price: $109.95
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Focusing on an integral part of pharmaceutical development, Sample Size Calculations in Clinical Research, Second Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. It provides sample size formulas and procedures for testing equality, noninferiority/superiority, and equivalence.A comprehensive and unified presentation of statistical concepts and practical applications, this book highlights the interactions between clinicians and biostatisticians, includes a well-balanced summary of current and emerging clinical issues, and explores recently developed statistical methodologies for sample size calculation. Whenever possible, each chapter provides a brief history or background, regulatory requirements, statistical designs and methods for data analysis, real-world examples, future research developments, and related references.One of the few books to systematically summarize clinical research procedures, this edition contains new chapters that focus on three key areas of this field. Incorporating the material of this book in your work will help ensure the validity and, ultimately, the success of your clinical studies.
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Book details

List price: $109.95
Edition: 2nd
Copyright year: 2007
Publisher: CRC Press LLC
Publication date: 8/22/2007
Binding: Hardcover
Pages: 480
Size: 6.50" wide x 9.25" long x 1.25" tall
Weight: 1.782
Language: English

Considerations Prior to Sample Size Calculation
Comparing Means
Large Sample Tests for Proportions
Exact Tests for Proportions
Tests for Goodness-of-Fit and Contingency
Comparing Time-to-Event Data
Group Sequential Methods
Comparing Variabilities
Bioequivalence Testing
Dose Response Studies
Microarray Studies
Bayesian Sample Size Calculation
Sample Size Calculation in Other Areas