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Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity Cocaine, GHB, and Substituted Amphetamines

ISBN-10: 1573316296

ISBN-13: 9781573316293

Edition: 2006

Authors: Francesco Fornai, Syed F. Ali, Yossef Itzhak

List price: $175.95
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Description:

Methamphetamine, MDMA, cocaine, PMA, GHB, and various solvents are the most widely abused drugs in Europe, the United States, Central America, South America, and Asia; and their use has dramatically increased over the last two decades. These drugs of abuse are known to cause neurotoxicity in several species, including not only rodents, dogs, and nonhuman primates, but also humans. The precise neurochemical mechanisms underlying this drug-induced neurotoxicity remain unclear. This volume explores this question, specifically addressing the following aspects: (1) the role of genomics and proteomics in drug-induced neurotoxicity, (2) drugs of abuse and medication development, (3) molecular biology and free radicals in drug-induced neurotoxicity, (4) substituted amphetamine-induced neurochemical changes and relationship to neurotoxicity, (5) drugs of abuse and imaging brain structure and function. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.
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Book details

List price: $175.95
Copyright year: 2006
Publisher: John Wiley & Sons, Incorporated
Publication date: 8/23/2006
Binding: Paperback
Pages: 552
Size: 6.00" wide x 9.00" long x 1.00" tall
Weight: 2.398

Genes and Drug of Abuse
Opposite Regulation of Cocaine-Induced Intracellular Signaling and Gene Expression by Dopamine D1 and D3 Receptors
Serial Analysis of Gene Expression (SAGE) in the Rat Striatum following Methamphetamine Administration
Dopamine Quinones Activate Microglia and Induce a Neurotoxic Gene Expression Profile: Relationship to Methamphetamine-Induced Nerve Ending Damage
Gene expression in the brain from Fluoxetine-injected mouse by using DNA microarray
Short-term effects of adolescent methylphenidate exposure on brain striatal gene.expression and sexual/endocrine parameters in male rats
Effects of L-carnitine Pre-treatment in Methamphetamine and 3-nitropropionic acid-induced neurotoxicity
Convergent Roles of Alpha-Synuclein, DA Metabolism and the Ubiquitin-Proteasome System in Nigrostriatal Toxicity
Association Study of the Dihydropyrimidinase-related Protein 2 Gene and Methamphetamine Psychosis
Repeated methamphetamine administration alters expression of the NMDA receptor channel I?2 subunit and kinesins in the mouse brain
Genes and Gene Expression in the Brain of Human Alcoholics
Association Study of the Tumor Necrosis Factor-I? Gene and Its 1A Receptor Gene with Methampetamine Dependence
Methamphetamine Neurotoxicity
Longitudinal Clinical course following Pharmacological Treatment of Methamphetamine Psychosis which persists after long-term Abstinence
Distinct Mechanisms Mediating Methamphetamine-Induced Neuronal Apoptosis and Dopamine Terminal Damage Share the Neuropeptide Substance P in the Striatum of Mice
Effects of Methamphetamine on the Cerebellar Cortex: a Preliminary Study
Age-Dependent Effects of Methamphetamine on VMAT-2
Methamphetamine, Morphine and their Combination: Acute Changes in Striatal Dopaminergic Transmission evaluated by Microdialysis in Awake Rats
In PC12 Cells Neurotoxicity Induced by Methamphetamine is Related to Proteasome Inhibition
Human Immunodeficiency Virus-1 Protein Tat and Methamphetamine Interactions
Over Expression of I?-Synuclein Following Methamphetamine: Is it Good or Bad?
Alterations in Blood-Brain Barrier Function by Morphine and Methamphetamine