DNA Repair and Mutagenesis

Name: DNA Repair and Mutagenesis
Price: 84.53 USD
Availability: InStock
ISBN: 9781555813192

ISBN-10: 1555813194

ISBN-13: 9781555813192

Edition: 2nd 2006 (Revised)

Authors: Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz

List price: $99.95

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Featuring more than 10,000 references and lavishly complemented by over 700 high-quality illustrations, DNA Repair and Mutagenesis, 2nd Edition, is a timely update to the original edition published in 1995. The addition of three new authors, including an expert in the field of structural biology, ensures a comprehensive review of the most current research in diverse subject areas. An ideal textbook for advanced undergraduate and graduate students, the book is also an essential resource for all scientists researching cellular responses to DNA damage. Completely reorganized, the new edition presents a significant overhaul of the existing chapters and introduces important new material…

Book details

List price: $99.95
Edition: 2nd
Copyright year: 2006
Publisher: ASM Press
Publication date: 11/22/2005
Binding: Hardcover
Pages: 1118
Size: 9.00" wide x 11.25" long x 2.00" tall
Weight: 6.182
Language: English

Richard D. Wood is an Honorary Research Fellow in the Civil and Computational Engineering Centre at Swansea University. He has over 20 years experience of teaching the course Nonlinear Continuum Mechanics for Finite Element Analysis at Swansea University, which he originally developed at the University of Arizona and also taught at IIT Roorkee, India and the Institute of Structural Engineering at the Technical University in Graz. Dr Wood's academic career has focused on finite element analysis, and he has written over 60 papers in international journals, and many chapter contributions, on topics related to nonlinear finite element analysis.




Introduction : biological responses to DNA damage



DNA damage



Introduction to mutagenesis



Reversal of base damage caused by UV radiation



Reversal of alkylation damage in DNA



Base excision repair



Nucleotide excision repair : general features and the process in prokaryotes



Nucleotide excision repair in eukaryotes : cell biology and genetics



Mechanism of nucleotide excision repair in eukaryotes



Heterogeneity of nucleotide excision repair in eukaryotic genomes



Alternative excision repair of DNA



Mismatch repair



Repair of mitochondrial DNA damage



The SOS responses of prokaryotes to DNA damage



Mutagenesis and translesion synthesis in prokaryotes



Recombinational repair, replication fork repair, and DNA damage tolerance



DNA damage tolerance and mutagenesis in eukaryotic cells



Managing DNA strand breaks in eukaryotic cells : repair pathway overview and homologous recombination



Managing DNA strand breaks in eukaryotic cells : nonhomologous end joining and other pathways



Cell cycle checkpoints : general introduction and mechanisms of DNA damage sensing



Cell cycle checkpoints : signal transmission and effector targets



Transcriptional responses to DNA damage



DNA damage and the regulation of cell fate



Xeroderma pigmentosum : a disease associated with defective nucleotide excision repair or defective translesion DNA synthesis



Other diseases associated with defects in nucleotide excision repair of DNA



Diseases associated with defective responses to DNA strand breaks



Diseases associated with disordered DNA helicase function



Additional diseases associated with defective responses to DNA damage



Hereditary diseases that implicate defective responses to DNA damage



DNA polymorphisms in gatekeeper and guardian genes