Antibiotics Actions, Origins, Resistance

ISBN-10: 1555812546

ISBN-13: 9781555812546

Edition: 2003

Authors: Christopher Walsh

List price: $99.95
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As antibiotics become deactivated through resistance and emerging bacterial diseases Christopher Walsh offers new insights into antibiotic modification and design. He shows how antibiotics work on targets and reviews recent strategies for finding innovative antibiotics to replace the last generation.
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Book details

List price: $99.95
Copyright year: 2003
Publisher: ASM Press
Publication date: 2/11/2003
Binding: Hardcover
Pages: 335
Size: 7.25" wide x 10.00" long x 1.00" tall
Weight: 1.738

Introduction to Antibiotics
Antibiotics: Initial Concepts
Validated Targets and Major Antibiotic Classes
Introduction to Major Antibiotic Classes and Modes of Action
Antibiotics That Act on Cell Wall Biosynthesis
Antibiotics That Block Bacterial Protein Biosynthesis
Antibiotics That Block DNA Replication and Repair: the Quinolones
Other Targets of Antibacterial Drugs
Antibiotic Resistance
Natural and Producer Immunity versus Acquired Resistance
Enzymatic Destruction or Modification of the Antibiotic by Resistant Bacteria
Antibiotic Resistance by Efflux Pumps
Antibiotic Resistance by Replacement or Modification of the Antibiotic Target
Antibiotic Biosynthesis
Regulation of Antibiotic Biosynthesis in Producer Organisms
Polyketide Antibiotic Biosynthesis: Assembly-Line Enzymology
Enzymatic Assembly Lines for Nonribosomal Peptide Antibiotics
Biosynthesis of Other Classes of Antibiotics
New Strategies for Finding Novel Antibiotics and Extending Their Lifetimes
New Looks at Targets
New Molecules
Contexts and Challenges for the Use of New Antibiotics
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