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Molecular Mechanisms of Cancer

ISBN-10: 1402060157

ISBN-13: 9781402060151

Edition: 2007

Authors: Georg F. Weber

List price: $149.99
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Description:

The knowledge of molecular defects that lead to cancer is increasing rapidly. This has created a need for a textbook that conveys a comprehensive review of this topic. "Molecular Mechanisms of Cancer," describes molecular processes whose deregulation is important in the formation of tumours. The material is developed from basic cell signalling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumour cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumour-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers. This book is an essential resource for researchers, graduate students and oncologists. It will also aid in drug discovery by identifying molecular targets. The growing insight generated by research into molecular carcinogenesis and the absence of comparably comprehensive and systematic textbooks makes this publication important and timely.
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Book details

List price: $149.99
Copyright year: 2007
Publisher: Springer
Publication date: 9/25/2007
Binding: Hardcover
Pages: 645
Size: 7.75" wide x 10.25" long x 1.25" tall
Weight: 3.696
Language: English

Introduction
General Mechanisms of Transformation
Theories of Carcinogenesis
Physiologic Correlates of Malignancy
Alterations Intrinsic to the Tumor Cells
Cell Division and Survival
Cellular Senescence
Invasiveness
Mechanisms of Regulation of Cancer-related Genes
DNA Repair
Epigenetic Regulation of Cancer-Associated Gene Products
Interaction of the Groups of Cancer-Related Gene Products
Interactions Between Host and Tumor
Structural Growth Control
The Organ Preference of Metastasis Formation
Angiogenesis
Interactions with the Immune System
Endocrine Dysregulation
Dormancy and Minimal Residual Disease
Molecular Mechanisms of Individual Malignancies
Epithelial Tumors
Hematologic Malignancies
Mesenchymal Tumors
Neurologic Tumors
Tumors of Serous Cavities
Embryonic Tumors
Index