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| Preface | |
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| Glossary | |
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| Elements of Continuum Mechanics | |
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| Biological Transport Processes | |
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| Micro-to Macro-scale Systems | |
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| Solute Transport | |
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| Basic Momentum, Heat, and Mass Transfer Concepts | |
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| Continuum Mechanics Axioms | |
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| Flow Field Descriptions | |
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| Lagrangian Description | |
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| Eulerian Description | |
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| Derivation Approaches | |
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| Conservation Laws | |
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| Mass Conservation | |
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| Momentum Conservation (Integral Approach) | |
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| Stress Tensors and Stress Vectors | |
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| Equation of Motion and its Special Cases | |
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| Force Balance Derivation | |
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| Energy Conservation | |
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| Heat and Mass Transfer Equations | |
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| Basic Heat and Mass Transfer Applications | |
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| Turbulent Flow Equations | |
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| Aspects of Turbulence | |
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| Turbulence Scales | |
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| Summary of Turbulence Modeling | |
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| Solution Techniques | |
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| Solution Methods for Differential Equations | |
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| Solution Procedures for the Navier-Stokes Equations | |
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| Similarity Theory | |
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| Integral Methods | |
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| Dimensional Analysis and Scaling | |
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| Two-Phase Flows | |
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| Modeling Approaches | |
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| Definitions | |
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| Phase Coupling | |
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| Mixture Models | |
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| Homogeneous and Non-Newtonian Flow Models | |
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| Drift-Flux Model | |
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| Separated Flow Models | |
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| Particle Trajectory Models | |
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| Species Mass Transfer | |
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| Porous Media Flow | |
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| Biomechanics Review | |
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| Introduction | |
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| Principal Stresses | |
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| Equilibrium Conditions | |
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| Deformation Analysis and Stress-Strain Relationships | |
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| Simplifications | |
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| Summary and Outlook | |
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| Homework Assignments | |
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| References | |
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| Biofluid Dynamics Concepts | |
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| Transport Phenomena | |
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| Biofluid-compartment Models | |
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| Tissue Heat and Mass Transfer | |
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| Joint Lubrication | |
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| Cell Transport and Microvascular Beds | |
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| The Cardiovascular System | |
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| Cardiovascular Transport Dynamics | |
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| The Heart | |
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| The Blood Vessels | |
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| Homework Problems | |
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| References | |
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| Analyses of Arterial Diseases | |
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| Vessel Occlusions | |
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| Atherosclerotic Plaque Formation | |
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| A Particle-Hemodynamics Model | |
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| A Pathway Model for Atherogenesis | |
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| Intimal Hyperplasia Development | |
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| Thrombogenesis | |
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| Particle-Hemodynamics | |
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| Equations of Particle Motion | |
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| Near-Wall Forces | |
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| Hemodynamic Wall Parameters | |
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| Treatment Option: Femoral End-to-Side Graft Bypass | |
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| Computational Fluid-Particle Dynamics Solution | |
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| Model Validation | |
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| Results for a Distal End-to-Side Femoral Bypass | |
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| Novel System Design and Discussion | |
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| Aneurysms | |
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| Aortic Aneurysms | |
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| Mechanisms of AAA Development | |
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| AAA-Wall Stress and Rupture | |
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| Treatment Option: Stent-graft Implants | |
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| Stented AAA-model Analysis | |
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| Basic Structure Equations | |
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| Numerical Method | |
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| Model Validations | |
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| Results and Discussion | |
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| Conclusions | |
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| Examples of Computerized Disease Management | |
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| Introduction | |
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| Image File Conversion Steps | |
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| A Stenosed Artery Model for Surgical Bypass Planning | |
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| AAA-Rupture Prediction | |
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| Homework Problems | |
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| References | |
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| Biofluid Mechanics of Organ Systems | |
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| The Lungs | |
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| Respiratory Tract Geometry | |
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| Pulmonary Disorders and Treatment Options | |
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| The Kidneys | |
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| Kidney Structure and Functions | |
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| Fluid Flow and Mass Transfer in an Artificial Kidney Model | |
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| The Liver | |
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| Liver Structure and Functions | |
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| Fluid Flow and Mass Transfer in a Liver Model | |
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| Homework Problems | |
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| References | |
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| Case Studies in Biofluid Dynamics | |
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| Prerequisites for Modeling and Simulating | |
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| Problem Recognition and System Conceptualization | |
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| Types of Models and Modeling Approaches | |
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| Mathematical Representation and System Simulation | |
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| Nanodrug Delivery in Microchannels | |
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| Flow in Microchannels | |
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| Numerical Solution Techniques | |
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| Microchannel Flow Effects | |
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| Controlled Nanodrug Delivery in Microchannels | |
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| Particle Deposition and Targeting in Human Lung Airways | |
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| Nanoparticle and Microparticle Depositions in a Human Upper Airway Model | |
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| Modeling Approach and Results | |
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| Numerical Method | |
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| Model Validations | |
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| Results and Discussion | |
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| Conclusions | |
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| Micro-drug Aerosol Targeting in Lung Airways | |
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| Fluid-Structure Interactions in Stented Aneurysms | |
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| Aneurysms and Their Possible Repairs | |
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| A Stented Abdominal Aortic Aneurysm Model | |
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| Introduction | |
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| Theory | |
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| Results | |
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| Discussion | |
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| Project Assignments | |
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| References | |
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| Appendices | |
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| Review of Tensor Calculus, Differential Operations, Integral Transformations, and ODE Solutions | |
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| Single-Phase Field Equations | |
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| Suitable CFD Solvers | |
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| Physical Properties | |
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| References | |
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| Index | |