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Preface | |
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Acknowledgments | |
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Overview | |
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Synopsis | |
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Concerns in Medicine | |
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Host-Parasite Equilibrium | |
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Development of the Acquired Immune System | |
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Clonal Selection Theory | |
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Antigens | |
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Definitions | |
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Factors Determining Antigenicity | |
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Examples of Antigens | |
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Innate Immunity | |
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Fundamental Characteristics | |
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Defensive Mechanisms | |
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Acute Phase Response (APR) | |
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Pathogen Recognition Systems | |
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Antibodies | |
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General Properties | |
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IgG | |
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IgM | |
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IgA | |
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IgE | |
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IgD | |
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Immunogenetics | |
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Genetic Control of Immunoglobulin Chain Synthesis | |
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Genetic Control of Human Leukocyte Antigens (HLAs) | |
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Genetic Control of the T-Cell Antigenic Receptor (TCR) | |
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Immunologic Assays | |
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Overview | |
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Protection Tests | |
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Agglutination Tests | |
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Precipitation Reactions | |
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Complement Fixation | |
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Fluorescent Antibody | |
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Western Blot | |
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Cell Counting and Flow Cytometry | |
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Reverse Transcription Polymerase Chain Reaction (RT-PCR) | |
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DNA Microarrays | |
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The Immune Response | |
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Humoral Immunity | |
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Cell-Mediated Immunity (CMI) | |
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Signal Transduction in Immune Cells | |
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Effective Immune Responses Require Communication Between a Wide Range of Cell Types | |
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Receptor Architecture and Fundamental Characteristics | |
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Signaling Molecules | |
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Pathways | |
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Inflammation | |
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Introduction | |
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Inflammation Process | |
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Kinetics | |
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Mediators of Inflammation | |
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Hypersensitivity Diseases | |
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Overview | |
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Anaphylaxis (Type I) Reactions | |
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Cell Surface Antigen-Antibody (Ag-Ab) Cytotoxicity (Type II) Reactions | |
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Antigen-Antibody (Ag-Ab) Complex (Type III) Reactions | |
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Delayed-Type Hypersensitivity (Type IV) Reactions | |
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Immunodeficiency Diseases | |
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Overview | |
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Developmental Immunodeficiency Disorders | |
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Acquired Immunodeficiency Syndrome (AIDS) | |
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Cytokine and Chemokine Deficiencies | |
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Senescence (Aging) of the Immune Response | |
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Autoimmune Disorders | |
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Overview | |
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Immunoregulation Breakdown | |
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Systemic Autoimmune Disorders | |
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Organ-Specific Autoimmune Disorders | |
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Immunologic Aspects of Transplantation | |
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Histocompatibility | |
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Complications of Organ Transplantation | |
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Immunosuppression | |
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Cancer Immunology | |
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Definition | |
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Oncogenes | |
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Cancer and the Immune System | |
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Cancer Immunotherapy | |
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Immunization | |
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Overview | |
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Specific Vaccines | |
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Adjuvants | |
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Study Questions and Answers | |