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Clinical Pharmacokinetics and Pharmacodynamics Concepts and Applications

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ISBN-10: 0781750091

ISBN-13: 9780781750097

Edition: 4th 2008 (Revised)

Authors: Malcolm Rowland, Thomas N. Tozer

List price: $94.99
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Description:

Formerly "Clinical Pharmacokinetics: Concepts and Clinical Applications, " this fully updated Fourth Edition has been retitled "Pharmacokinetics and Pharmacodynamics: Concepts and Clinical Applications" to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.
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Book details

List price: $94.99
Edition: 4th
Copyright year: 2008
Publisher: Lippincott Williams & Wilkins
Publication date: 1/28/2010
Binding: Hardcover
Pages: 864
Size: 7.25" wide x 10.25" long x 1.50" tall
Weight: 3.652
Language: English

Preface
Nonproprietary and Brand Names of Drugs in Text and Illustrations
Definition of Symbols
Basic Considerations
Therapeutic Relevance
Fundamental Concepts and Terminology
Exposure and Response after a Single Dose
Kinetics Following an Intravenous Bolus Dose
Membranes and Distribution
Elimination
Kinetics Following an Extravascular Dose
Absorption
Response Following a Single Dose
Therapeutic Regimens
Therapeutic Window
Constant-Rate Input
Multiple-Dose Regimens
Individualization
Variability
Genetics
Age, Weight, and Gender
Disease
Nonlinearities
Drug Interactions
Initiating and Managing Therapy
Supplemental Topics
Distribution Kinetics
Metabolites and Drug Response
Protein Drugs
Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data
Appendices
Assessment of AUC
Ionization and the pH Partition Hypothesis
Distribution of Drugs Extensively Bound to Plasma Proteins
Plasma-to-Blood Concentration Ratio
Well-stirred Model of Hepatic Clearance
Absorption Kinetics
Wagner-Nelson Method
Mean Residence Time
Amount of Drug in Body on Accumulation to Plateau
Answers to Study Problems
Index