Clinical Pharmacokinetics and Pharmacodynamics Concepts and Applications
Edition: 4th 2008 (Revised)
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Formerly "Clinical Pharmacokinetics: Concepts and Clinical Applications, " this fully updated Fourth Edition has been retitled "Pharmacokinetics and Pharmacodynamics: Concepts and Clinical Applications" to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.
List price: $94.99
Copyright year: 2008
Publisher: Lippincott Williams & Wilkins
Publication date: 1/28/2010
Size: 7.25" wide x 10.25" long x 1.50" tall
|Nonproprietary and Brand Names of Drugs in Text and Illustrations|
|Definition of Symbols|
|Fundamental Concepts and Terminology|
|Exposure and Response after a Single Dose|
|Kinetics Following an Intravenous Bolus Dose|
|Membranes and Distribution|
|Kinetics Following an Extravascular Dose|
|Response Following a Single Dose|
|Age, Weight, and Gender|
|Initiating and Managing Therapy|
|Metabolites and Drug Response|
|Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data|
|Assessment of AUC|
|Ionization and the pH Partition Hypothesis|
|Distribution of Drugs Extensively Bound to Plasma Proteins|
|Plasma-to-Blood Concentration Ratio|
|Well-stirred Model of Hepatic Clearance|
|Mean Residence Time|
|Amount of Drug in Body on Accumulation to Plateau|
|Answers to Study Problems|