Clinical Pharmacokinetics and Pharmacodynamics Concepts and Applications

Name: Clinical Pharmacokinetics and Pharmacodynamics Concepts and Applications
Price: 54.98 USD
Availability: InStock
ISBN: 9780781750097

ISBN-10: 0781750091

ISBN-13: 9780781750097

Edition: 4th 2008 (Revised)

Authors: Malcolm Rowland, Thomas N. Tozer

List price: $94.99

30 day, 100% satisfaction guarantee!

Sell

Get cash fast!

Marketplace

2 new & used from $54.98

what's this?

Rush Rewards U
Members Receive:

You have reached 400 XP and carrot coins. That is the daily max!

Description:

Formerly "Clinical Pharmacokinetics: Concepts and Clinical Applications, " this fully updated Fourth Edition has been retitled "Pharmacokinetics and Pharmacodynamics: Concepts and Clinical Applications" to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts…

Book details

List price: $94.99
Edition: 4th
Copyright year: 2008
Publisher: Lippincott Williams & Wilkins
Publication date: 1/28/2010
Binding: Hardcover
Pages: 864
Size: 7.25" wide x 10.25" long x 1.50" tall
Weight: 4.158
Language: English



Preface


Nonproprietary and Brand Names of Drugs in Text and Illustrations


Definition of Symbols



Basic Considerations



Therapeutic Relevance



Fundamental Concepts and Terminology



Exposure and Response after a Single Dose



Kinetics Following an Intravenous Bolus Dose



Membranes and Distribution



Elimination



Kinetics Following an Extravascular Dose



Absorption



Response Following a Single Dose



Therapeutic Regimens



Therapeutic Window



Constant-Rate Input



Multiple-Dose Regimens



Individualization



Variability



Genetics



Age, Weight, and Gender



Disease



Nonlinearities



Drug Interactions



Initiating and Managing Therapy



Supplemental Topics



Distribution Kinetics



Metabolites and Drug Response



Protein Drugs



Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data


Appendices



Assessment of AUC



Ionization and the pH Partition Hypothesis



Distribution of Drugs Extensively Bound to Plasma Proteins



Plasma-to-Blood Concentration Ratio



Well-stirred Model of Hepatic Clearance



Absorption Kinetics



Wagner-Nelson Method



Mean Residence Time



Amount of Drug in Body on Accumulation to Plateau



Answers to Study Problems


Index