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Biochemistry of the Eye

ISBN-10: 0750690747

ISBN-13: 9780750690744

Edition: 1994

Authors: David R. Whikehart

List price: $54.95
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Description:

This specialized text presents a review of general biochemistry and an in-depth exploration of biochemistry unique to the eye. As a readable introduction to this challenging topic, it describes the molecular structures and biochemical events that occur in the eye. Specific clinical examples link basic science to clinical practice and provide a concrete basis for understanding complex concepts. This edition includes new, updated information in revised chapters plus two additional chapters on ocular fluids and pathology. General biochemistry is discussed in each chapter, with examples of biochemical pathology and disease processes such as age-related cataract formation and ocular diabetes.
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Book details

List price: $54.95
Copyright year: 1994
Publisher: Elsevier - Health Sciences Division
Publication date: 9/20/1994
Binding: Paperback
Pages: 198
Size: 9.00" wide x 11.25" long x 0.75" tall
Weight: 1.386
Language: English

Four-Color Sectionp. xv
Water and Ocular Fluids: Physical Chemistry of Ocular Fluidsp. 1
Waterp. 1
Hydrogen Bondsp. 3
Weak Electrolytes and Buffers in Waterp. 3
The Henderson-Hasselbalch Equationp. 5
Biological Buffers in Ocular and Other Body Fluids and Tissuesp. 6
Ocular Fluidsp. 7
Blood in the Ocular Globep. 7
Aqueous Fluidp. 9
The Vitreous (Vitreous Body)p. 10
Precorneal Tearsp. 11
Summaryp. 12
Problemsp. 13
Proteins: Essential Components of the Eyep. 15
Crystallinsp. 22
Characteristicsp. 22
The Aging Process and Effects on Crystallinsp. 27
Cataract Formationp. 28
Rhodopsin and Cone Pigment Proteinsp. 33
Mucous Glycoproteinsp. 40
Collagenp. 41
Ocular, Structural Rolesp. 45
Summaryp. 50
Problemsp. 51
Enzymes: Ocular Catalystsp. 55
Michaelis-Menten Enzymesp. 56
Allosteric Enzymesp. 60
Enzyme Inhibationp. 62
Lysozymep. 64
Na, K-ATPasep. 68
Lactate Dehydrogenasep. 70
Aldose Reductasep. 75
Matrix Metalloproteinasesp. 77
Summaryp. 81
Problemsp. 82
Carbohydratesp. 85
Energy Metabolismp. 89
Glycolysisp. 92
The Anaerobic Exit of Glycolysisp. 95
The Aerobic Exit of Glycolysisp. 97
Glycogen Formation and Degradationp. 102
The Pentose Shuntp. 103
Other Aspects of Carbohydrate Metabolismp. 105
Ocular Comparative Metabolismp. 106
Problems of Carbohydrate Transport and Metabolism: Diabetes and Galactosemiap. 108
Glucose Transport Into Cells and Its Relationship to Diabetesp. 109
Type 1 Diabetesp. 110
Type 2 Diabetesp. 115
Ocular Pathological Effects Produced by Diabetesp. 117
Introduction to Galactosemiap. 122
Ocular Effects of Galactosemiap. 123
Structural Carbohydratesp. 123
Sugar Oligomers and Polymersp. 123
Summaryp. 128
Problemsp. 129
Lipidsp. 133
Lipid Classcificationsp. 133
Fatty Acidsp. 133
Triacylglycerolsp. 134
Phospholipidsp. 136
Isoprenoidsp. 138
Estersp. 139
Eicosanoidsp. 139
Glycolipidsp. 140
Cell Membranesp. 142
Lipid Componentsp. 142
Protein Componentsp. 144
Carbohydrate Componentsp. 144
Membrane Component Summaryp. 145
Transport: An Essential Membrane Functionp. 145
Precorneal Tear Film Lipidsp. 147
Lipids of the Retinap. 149
Vitamin Ap. 150
Glycolopid Storage Diseases and Visionp. 153
Summaryp. 154
Problemsp. 155
Hormonesp. 159
Hormone General Functions: Chemical Micromanagersp. 159
The Endocrine System (Neuroendocrine System)p. 161
Hormone Effects, "Shelf Life," and Concentrationsp. 162
Hormones: Chemical Classesp. 163
Plasma Membrane Hormones and Their Receptors: Mechanismsp. 165
Cyclic Nucleotide Mechanismsp. 165
Inositol Trisphosphate/Ca[superscript +2] Mechanismsp. 169
Nitric Oxidep. 171
Light Transduction: A cGMP Mechanismp. 171
Graves' Disease: Autoimmune Mischief with Thyroid Hormonesp. 176
DNA Binding Hormones: Mechanismp. 179
Paracrine Hormonesp. 182
Summaryp. 185
Problemsp. 186
Nucleic Acidsp. 191
Nucleic Acid Biochemistryp. 191
Deoxyribonucleic Acidp. 191
DNA Replicationp. 195
Ribonucleic Acidp. 198
Transcription of RNAp. 199
The Genetic Code and "Nonsense" Sequencesp. 200
The Formation of Messenger RNAp. 202
Protein Synthesis (Translation)p. 202
Mutations to DNA and to Nucleic Acid Processingp. 210
Molecular Biology of the Crystallinsp. 213
Normal Crystallinsp. 213
Crystallin and Other Protein Genetic Defectsp. 218
Viral Intervention in the Corneap. 220
Potential Gene Therapy of Rentinal Diseasep. 223
Summaryp. 225
Problemsp. 226
Ocular Neurochemistryp. 231
Neurotransmitters and Receptor Proteins and Their Properties (Including Ocular Autonomic Functions)p. 234
Neurochemistry of the Retinap. 239
Ocular Neurochemical Pathologyp. 245
Summaryp. 246
Problemsp. 247
Ocular Immunochemistryp. 249
Review of Immunoglobulinsp. 249
Ocular Immunoglobulinsp. 256
Complementp. 257
Complement of the Eyep. 260
Inflammationp. 260
Ocular Inflammationp. 266
Summaryp. 267
Problemsp. 267
Ocular Biochemical Degradation: Aging and Pathological Processesp. 271
Cellular Apoptosisp. 271
Apoptosis in Ocular Cellsp. 273
Liquefaction of the Vitreousp. 275
Important Vitreal Gel Componentsp. 275
Molecular Aging Effects and Liquefactionp. 277
Chemical Burns of the Corneap. 277
Early Chemical Damagep. 278
Immunochemical Damagep. 278
Summaryp. 279
Problemsp. 280
Glossaryp. 283
Answers to Problemsp. 306
Indexp. 313
Table of Contents provided by Rittenhouse. All Rights Reserved.