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Guide to Cytochromes P450 Structure and Function, Second Edition

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ISBN-10: 0748408975

ISBN-13: 9780748408979

Edition: 2nd 2001 (Revised)

Authors: David F. V. Lewis

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Cytochromes are coloured iron-containing proteins that transfer electrons during cellular respiration and photosynthesis. The Cytochrome P450 family of enzymes catalyze reactions whereby water-insoluble drugs or metabolites, that would otherwise reach toxic levels in cell membranes, are rendered suitably water-soluble to leave the cell and be excreted in the urine. Due to the extensive nature of this subject, which is an area of intense scientific interest, the field is rapidly advancing and there is a need for new textbooks to keep abreast of the latest developments. The book fulfils that role in providing a fast-track approach for those coming into the P450 field, either at postgraduate…    
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Book details

Edition: 2nd
Copyright year: 2001
Publisher: CRC Press LLC
Publication date: 8/23/2001
Binding: Hardcover
Pages: 240
Size: 9.00" wide x 6.00" long x 5.00" tall
Weight: 0.836

Colour plates
List of tables
List of figures
Chemical abbreviations
Discovery of an enzyme superfamily
Occurrence and distribution
Isolation and purification
Characterization and detection
Genetic polymorphisms and allelic variants: protein sequence alignments
Biotechnological applications
Nomenclature note: cytochromes, peroxidases and P450
Evolution of the P450 superfamily
P450 phylogeny
P450 sequences
Nomenclature of P450 genes and enzymes
The P450 catalytic cycle
Stages in the reaction
Thermodynamics of the P450 reaction, rates of electron transfer and kinetics
Coupling of spin and redox equilibria
Factors influencing the rate of substrate turnover
Appendix--Factors influencing rates and clearance in P450 reactions: QSARs
Substrate selectivity and metabolism
Endogenous substrates
Exogenous substrates
Criteria governing substrate selectivity for human hepatic P450s
Toxicity mediated by P450 enzymes
Quantitative structure--activity relationships (QSARs) in P450 substrates
Regulation of P450 enzymes
Mechanisms of P450 regulation and gene expression
Toxic consequences of induction: predicting toxicity via the COMPACT method
QSARs in P450 inducers and nuclear receptor ligand binding
Inhibition of P450 enzymes
QSARs for P450 inhibitors
The structures of cytochromes P450
X-ray crystallography
Site-directed mutagenesis and residue modification
Molecular modelling studies
Molecular orbital calculations
Glossary of terms