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Guide to Cytochrome P450 Structure and Function

ISBN-10: 0748408975

ISBN-13: 9780748408979

Edition: 2nd 2001 (Revised)

Authors: David F. V. Lewis

List price: $140.00
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Description:

Cytochromes are coloured iron-containing proteins that transfer electrons during cellular respiration and photosynthesis. The Cytochrome P450 family of enzymes catalyze reactions whereby water-insoluble drugs or metabolites, that would otherwise reach toxic levels in cell membranes, are rendered suitably water-soluble to leave the cell and be excreted in the urine. Due to the extensive nature of this subject, which is an area of intense scientific interest, the field is rapidly advancing and there is a need for new textbooks to keep abreast of the latest developments. The book fulfils that role in providing a fast-track approach for those coming into the P450 field, either at postgraduate level or in particular within the pharmaceutical industry.A Guide to Cytochrome P450 Structure and Function acts as an adjunct to the previous book Cytochromes P450: Structure, Function and Mechanism. Itreviews the current status of the P450 field in terms of our present knowledge and understanding of the enzymes structure and function, including their multiplicity of forms, diversity of substrates, and selectivity. This is brought together with the latest research topics, including pharmacogenetics, regulation, human DMEs, toxicity screening and molecule modeling, to provide a fast-track approach for those new to the field.
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Book details

List price: $140.00
Edition: 2nd
Copyright year: 2001
Publisher: CRC Press LLC
Publication date: 8/23/2001
Binding: Hardcover
Pages: 240
Size: 9.00" wide x 6.00" long x 5.00" tall
Weight: 0.836
Language: English

Colour plates
List of tables
List of figures
Acknowledgements
Abbreviations
Chemical abbreviations
Symbols
Preface
Foreword
Introduction
Discovery of an enzyme superfamily
Occurrence and distribution
Isolation and purification
Characterization and detection
Genetic polymorphisms and allelic variants: protein sequence alignments
Biotechnological applications
Nomenclature note: cytochromes, peroxidases and P450
Evolution of the P450 superfamily
Introduction
P450 phylogeny
P450 sequences
Nomenclature of P450 genes and enzymes
The P450 catalytic cycle
Introduction
Stages in the reaction
Thermodynamics of the P450 reaction, rates of electron transfer and kinetics
Coupling of spin and redox equilibria
Factors influencing the rate of substrate turnover
Appendix--Factors influencing rates and clearance in P450 reactions: QSARs
Substrate selectivity and metabolism
Introduction
Endogenous substrates
Exogenous substrates
Criteria governing substrate selectivity for human hepatic P450s
Toxicity mediated by P450 enzymes
Quantitative structure--activity relationships (QSARs) in P450 substrates
Regulation of P450 enzymes
Introduction
Mechanisms of P450 regulation and gene expression
Toxic consequences of induction: predicting toxicity via the COMPACT method
QSARs in P450 inducers and nuclear receptor ligand binding
Inhibition of P450 enzymes
QSARs for P450 inhibitors
The structures of cytochromes P450
Introduction
X-ray crystallography
Spectroscopy
Site-directed mutagenesis and residue modification
Molecular modelling studies
Molecular orbital calculations
Conclusions
Glossary of terms
Bibliography
References
Index