Guide to Cytochromes P450 Structure and Function, Second Edition

Name: Guide to Cytochromes P450 Structure and Function, Second Edition
Price: 218.5 USD
Availability: InStock
ISBN: 9780748408979

ISBN-10: 0748408975

ISBN-13: 9780748408979

Edition: 2nd 2001 (Revised)

Authors: David F. V. Lewis

List price: $155.00

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Description:

Cytochromes are coloured iron-containing proteins that transfer electrons during cellular respiration and photosynthesis. The Cytochrome P450 family of enzymes catalyze reactions whereby water-insoluble drugs or metabolites, that would otherwise reach toxic levels in cell membranes, are rendered suitably water-soluble to leave the cell and be excreted in the urine. Due to the extensive nature of this subject, which is an area of intense scientific interest, the field is rapidly advancing and there is a need for new textbooks to keep abreast of the latest developments. The book fulfils that role in providing a fast-track approach for those coming into the P450 field, either at postgraduate…

Book details

List price: $155.00
Edition: 2nd
Copyright year: 2001
Publisher: CRC Press LLC
Publication date: 8/23/2001
Binding: Hardcover
Pages: 240
Size: 9.00" wide x 6.00" long x 5.00" tall
Weight: 0.836



Colour plates


List of tables


List of figures


Acknowledgements


Abbreviations


Chemical abbreviations


Symbols


Preface


Foreword



Introduction



Discovery of an enzyme superfamily



Occurrence and distribution



Isolation and purification



Characterization and detection



Genetic polymorphisms and allelic variants: protein sequence alignments



Biotechnological applications



Nomenclature note: cytochromes, peroxidases and P450



Evolution of the P450 superfamily



Introduction



P450 phylogeny



P450 sequences



Nomenclature of P450 genes and enzymes



The P450 catalytic cycle



Introduction



Stages in the reaction



Thermodynamics of the P450 reaction, rates of electron transfer and kinetics



Coupling of spin and redox equilibria



Factors influencing the rate of substrate turnover



Appendix--Factors influencing rates and clearance in P450 reactions: QSARs



Substrate selectivity and metabolism



Introduction



Endogenous substrates



Exogenous substrates



Criteria governing substrate selectivity for human hepatic P450s



Toxicity mediated by P450 enzymes



Quantitative structure--activity relationships (QSARs) in P450 substrates



Regulation of P450 enzymes



Introduction



Mechanisms of P450 regulation and gene expression



Toxic consequences of induction: predicting toxicity via the COMPACT method



QSARs in P450 inducers and nuclear receptor ligand binding



Inhibition of P450 enzymes



QSARs for P450 inhibitors



The structures of cytochromes P450



Introduction



X-ray crystallography



Spectroscopy



Site-directed mutagenesis and residue modification



Molecular modelling studies



Molecular orbital calculations



Conclusions


Glossary of terms


Bibliography


References


Index