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Apoptosis in Toxicology

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ISBN-10: 0748408150

ISBN-13: 9780748408153

Edition: 1999

Authors: Ruth Roberts, Gerry Cohen

List price: $139.95
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Apoptosis in Toxicology is the first book to focus on the molecular regulation of apoptosis with particular emphasis on toxicant action. Cell survival signalling and its perturbation is addressed at the genetic and biochemical level, including key survival and death genes, survival signalling, commitment to apoptosis and recruitment of the initiator and executioner caspases.Emphasis is given to the role apoptosis plays in the action of toxicants in the brain, the immune system, the reproductive organs, the kidney and the liver. The ability of drugs to regulate apoptosis either as a target or as an adverse effect is discussed with particular reference to cancer chemotherapy. The many methods…    
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Book details

List price: $139.95
Copyright year: 1999
Publisher: CRC Press LLC
Publication date: 12/2/1999
Binding: Hardcover
Pages: 248
Size: 7.25" wide x 10.00" long x 0.75" tall
Weight: 1.540
Language: English

Apoptosis: Basic Mechanisms and Relevance to Toxicology
Toxicological Consequences of Caspase Inhibition and Activation
Modulation of Apoptosis in Immunotoxicology
Apoptosis in Male Reproductive Toxicology
Apoptosis in Female Reproductive Toxicology
Modulation of Apoptosis in Renal Toxicity
Role of Apoptosis in Neuronal Toxicology
Perturbation of Apoptosis as a Mechanism of Action of Nongenotoxic Carcinogens
Toxic Mechanisms Mediated by Gene Expression
Detection and Biomarkers of Apoptosis