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Adrenal in Toxicology Target Organ and Modulator of Toxicity

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ISBN-10: 0748403302

ISBN-13: 9780748403301

Edition: 1996

Authors: P. W. Harvey

List price: $159.95
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Description:

The adrenal gland is vitally important to health and secretes hormones that control many bodily processes ranging from normal metabolism to the response to stressful circumstances. The corticosteroid hormones are the basis for anti-inflammatory medicines and are very widely prescribed. Changes in the function of the adrenal gland, either naturally through stress or disease, or through the action of drugs and chemicals, can have a major impact on the body.; This text focuses on adrenal toxicity, examining how drugs and chemicals can directly and indirectly affect this gland. Coverage includes: classification of the types of adrenal and endocrine toxicity; the mechanistic and molecular basis of toxicity; reasons why the adrenal is the most common target organ in the endocrine system; drug toxicity specific to patients with adrenal disorders; drug- corticosteroid interactions; adverse drug reactions; and how the adrenal gland is vital in tolerance to toxic insult.
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Book details

List price: $159.95
Copyright year: 1996
Publisher: CRC Press LLC
Publication date: 3/28/1996
Binding: Hardcover
Pages: 330
Size: 0.61" wide x 0.93" long x 0.90" tall
Weight: 1.540
Language: English

Preface
Contributors
Introduction to Adrenal Gland Involvement in Toxicology
An overview of adrenal gland involvement in toxicology: from target organ to stress and glucocorticosteroid modulation of toxicity
General Endocrinology, Pharmacology and Pathology of the Adrenal Gland Related to Species, Sex and Age and Glucocorticosteroid Actions
Adrenal morphology and hormone synthesis and regulation
Transport, actions and metabolism of adrenal hormones and pathology and pharmacology of the adrenal gland
Molecular and systems pharmacology of glucocorticosteroids
The Adrenal Gland as a Target Organ
The adrenal cortex as a toxicological target organ
The adrenal medulla as a toxicological target organ
Adrenocortical and Glucocorticosteroid Modulation of Toxicity
Glucocorticosteroid modulation of toxicity
Glucocorticosteroids: deleterious effects on neurons and potential exacerbation of environmental neurotoxicity
Glucocorticosteroids, stress and developmental toxicology
Glucocorticosteroids and immunotoxicity
Clinical Interfaces: Adrenal and Corticosteroid Involvement in Human Toxicology and Extrapolation to Man
Corticosteroid adverse effects and drug interactions in man
Adverse drug reactions and the adrenal glands: a pharmacoepidemiological approach
Experimental adrenal toxicity: significance of findings and relevance to man
Index