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| Preface to the First Edition | |
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| Preface to the Third Edition | |
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| Introduction | |
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| Chapter outline | |
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| Historical aspects | |
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| Types of toxic substance | |
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| Types of exposure | |
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| Dose-response relationship | |
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| Summary and learning objectives | |
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| Questions | |
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| Bibliography | |
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| Disposition of Toxic compounds | |
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| Chapter outline | |
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| Absorption of toxic compounds | |
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| Distribution of toxic compounds | |
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| Excretion of toxic compounds | |
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| Summary and learning objectives | |
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| Questions | |
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| Bibliography | |
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| Metabolism of Foreign Compounds | |
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| Chapter outline | |
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| Introduction | |
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| Factors affecting toxic responses | |
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| Summary and learning objectives | |
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| Questions | |
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| Bibliography | |
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| Types of Exposure and Response | |
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| Chapter outline | |
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| Types of exposure | |
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| Route of exposure | |
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| Types of toxic response | |
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| Biomarkers | |
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| Summary and learning objectives | |
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| Questions | |
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| Bibliography | |
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| Drugs as Toxic Substances | |
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| Chapter outline | |
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| Introduction | |
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| Paracetamol | |
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| Aspirin (salicylate) | |
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| Hydralazine | |
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| Halothane | |
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| Debrisoquine | |
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| Thalidomide | |
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| Drug interactions | |
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| Altered responsiveness: glucose-6-phosphate dehydrogenase deficiency | |
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| Summary and learning objectives | |
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| Questions | |
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| Bibliography | |
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| Industrial Toxicology | |
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| Chapter outline | |
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| Industrial chemicals | |
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| Means of exposure | |
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| Toxic effects | |
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| Vinyl chloride | |
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| Cadmium | |
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| Aromatic amines | |
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| Asbestos | |
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| Legislation | |
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| Summary and learning objectives | |
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| Questions | |
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| Bibliography | |
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| Food Additives and Contaminants | |
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| Chapter outline | |
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| Introduction | |
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| Tartrazine | |
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| Saccharin | |
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| Food contaminants | |
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| Summary and learning objectives | |
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| Questions | |
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| Bibliography | |
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| Pesticides | |
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| Chapter outline | |
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| Introduction | |
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| DDT | |
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| Organophosphorus compounds | |
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| Paraquat | |
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| Fluoroacetate | |
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| Summary and learning objectives | |
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| Questions | |
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| Bibliography | |
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| Environmental Pollutants | |
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| Chapter outline | |
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| Introduction | |
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| Air pollution | |
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| Particulates | |
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| Acid rain | |
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| Lead pollution | |
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| Water pollution | |
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| Arsenic | |
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| Food chains | |
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| Endocrine disruptors | |
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| Mercury and methylmercury | |
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| Summary and learning objectives | |
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| Questions | |
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| Bibliography | |
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| Natural Products | |
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| Chapter outline | |
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| Plant toxins | |
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| Animal toxins | |
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| Fungal toxins | |
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| Microbial toxins | |
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| Summary and learning objectives | |
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| Questions | |
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| Bibliography | |
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| Household Products | |
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| Chapter outline | |
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| Introduction | |
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| Carbon monoxide | |
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| Antifreeze: ethylene glycol | |
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| Cyanide | |
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| Alcohol | |
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| Glue sniffing and solvent abuse | |
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| Antidotes and the treatment of poisoning | |
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| Summary and learning objectives | |
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| Questions | |
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| Bibliography | |
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| Toxicity Testing and Risk Assessment | |
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| Chapter outline | |
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| Introduction | |
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| Evaluation of toxicity | |
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| Acute toxicity tests | |
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| Sub-acute toxicity tests | |
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| Chronic toxicity tests | |
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| Testing in vitro | |
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| Risk assessment and interpretation of toxicological data | |
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| Conclusions | |
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| Summary and learning objectives | |
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| Questions | |
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| Bibliography | |
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| Answers to questions | |
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| Glossary | |
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| Index | |