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| Preface | |
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| General Aspects of Inheritance | |
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| Genetics and the Organism | |
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| Genes as Determinants of the Inherent Properties of Species | |
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| Genetic Variation | |
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| Methodologies Used in Genetics | |
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| Genes, the Environment, and the Organism | |
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| Patterns of Inheritance | |
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| Mendel's Experiments | |
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| Using Genetic Ratios | |
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| Sex Chromosomes and Sex-Linked Inheritance | |
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| Human Genetics | |
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| Chromosomal Basis of Heredity | |
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| Historical Development of the Chromosome Theory | |
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| Mendelian Genetics in Eukaryotic Life Cycles | |
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| Topography of the Chromosome Set | |
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| Three-Dimensional Structure of Chromosomes | |
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| Sequence Organization | |
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| Gene Interaction | |
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| From Genes to Phenotypes | |
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| A Diagnostic Test for Alleles | |
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| Interactions Between the Alleles of One Gene | |
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| Gene Interaction and Modified Dihybrid Ratios | |
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| Gene Interaction in Petal Color of Foxgloves | |
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| Gene Interaction in Coat Color of Mammals | |
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| Penetrance and Expressivity | |
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| Chi-Square Test | |
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| Genetic Mapping | |
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| Basic Eukaryotic Chromosome Mapping | |
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| The Discovery of Linkage | |
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| Recombination | |
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| Linkage Symbolism | |
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| Linkage of Genes on the X Chromosome | |
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| Linkage Maps | |
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| Three-Point Testcross | |
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| Interference | |
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| Calculating Recombinant Frequencies from Selfed Dihybrids | |
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| Examples of Linkage Maps | |
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| Chi-Square Test for Linkage | |
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| Mapping with Molecular Markers | |
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| Linkage Mapping by Recombination in Humans | |
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| Nature of Crossing-Over | |
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| Specialized Eukaryotic Chromosome Mapping Techniques | |
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| Accurate Calculation of Large Map Distances | |
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| Analysis of Single Meioses | |
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| Mapping Genes by Mitotic Segregation and Recombination | |
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| Mapping by In Situ Hybridization | |
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| Mapping Human Genes by Using Human-Rodent Somatic Cell Hybrids | |
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| Gene Transfer in Bacteria and Their Viruses | |
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| Working with Microorganisms | |
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| Bacterial Conjugation | |
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| Bacterial Transformation | |
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| Bacteriophage Genetics | |
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| Transduction | |
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| Chromosome Mapping | |
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| Bacterial Gene Transfer in Review | |
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| Molecular Genetics | |
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| The Structure and Replication of DNA | |
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| DNA: The Genetic Material | |
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| Structure of DNA | |
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| Replication of DNA | |
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| Mechanism of DNA Replication | |
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| Genetics of DNA Function | |
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| How Genes Work | |
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| Gene-Protein Relations | |
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| Genetic Fine Structure | |
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| Mutational Sites | |
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| Complementation | |
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| Molecular Biology of Gene Function | |
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| Properties of RNA | |
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| Transcription | |
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| Transcription and RNA Polymerase | |
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| Eukaryotic RNA | |
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| Translation | |
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| Genetic Code | |
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| Protein Synthesis | |
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| Universality of Genetic Information Transfer | |
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| Functional Division of Labor in the Gene Set | |
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| Regulation of Gene Transcription | |
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| Basic Control Circuits | |
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| Discovery of the lac System: Negative Control | |
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| Catabolite Repression of the lac Operon: Positive Control | |
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| Positive and Negative Control | |
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| Dual Positive and Negative Control: The Arabinose Operon | |
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| Metabolic Pathways | |
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| Additional Examples of Control: Attenuation | |
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| Lambda Phage: A Complex of Operons | |
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| Transcription: An Overview of Gene Regulation in Eukaryotes | |
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| Regulation of Transcription Factors | |
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| Epigenetic Inheritance | |
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| Recombinant DNA Technology | |
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| Making Recombinant DNA | |
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| Cloning a Specific Gene | |
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| Using Cloned DNA | |
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| Applications of Recombinant DNA Technology | |
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| In Vitro Mutagenesis | |
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| RFLP Mapping | |
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| Reverse Genetics | |
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| Expressing Eukaryotic Genes in Bacteria | |
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| Recombinant DNA Technology in Eukaryotes | |
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| Gene Therapy | |
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| Using Recombinant DNA to Detect Disease Alleles Directly | |
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| Genomics | |
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| Genomics: An Overview | |
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| Genome Projects: Practical Considerations | |
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| Structural Genomics | |
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| Functional Genomics | |
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| Generation of Genetic Variation | |
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| Gene Mutation | |
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| How DNA Changes Affect Phenotype | |
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| Somatic Versus Germinal Mutation | |
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| Mutant Types | |
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| Occurrence of Mutations | |
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| Selective Systems | |
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| Mutation Induction | |
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| Mutation and Cancer | |
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| Mutagens in Genetic Dissection | |
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| Mutation Breeding | |
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| Mechanisms of Gene Mutation | |
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| Molecular Basis of Gene Mutations | |
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| Spontaneous Mutations | |
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| Induced Mutations | |
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| Reversion Analysis | |
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| Relation Between Mutagens and Carcinogens | |
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| Biological Repair Mechanisms | |
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| Repair Defects and Human Diseases | |
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| Chromosome Mutation I: Changes in Chromosome Structure | |
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| Origin of Changes in Chromosome Structure | |
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| Deletions | |
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| Duplications | |
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| Inversions | |
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| Translocations | |
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| Diagnosis of Rearrangments by Tetrad Analysis | |
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| Chromosome Mutation II: Changes in Chromosome Number | |
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| Aberrant Euploidy | |
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| Aneuploidy | |
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| Mechanisms of Gene Imbalance | |
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| Chromosome Mechanics in Plant Breeding | |
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| Mechanisms of Recombination | |
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| Breakage and Reunion of DNA Molecules | |
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| Chiasmata: The Crossover Points | |
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| Genetic Results Leading to Recombination Models | |
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| Holliday Model | |
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| Enzymatic Mechanism of Recombination | |
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| Transposable Genetic Elements | |
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| Controlling Elements in Maize | |
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| Bacterial Insertion Sequences | |
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| Prokaryotic Transposons | |
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| Mechanism of Transposition in Prokaryotes | |
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| Review of Transposable Elements in Prokaryotes | |
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| Molecular Nature of Transposable Elements in Eukaryotes | |
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| Review of Transposable Elements in Eukaryotes | |
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| Development | |
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| Extranuclear Genes | |
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| Origin of Extranuclear Genes | |
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| Structure of Organelle Chromosomes | |
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| Organelle Mutations | |
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| Inheritance of Organelle Genes and Mutations | |
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| Recombination of Extranuclear DNA | |
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| Cytoplasmic Male Sterility | |
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| Mitochondria and Aging | |
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| Cancer as a Genetic Disease | |
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| Cancer and the Control of Cell Number: An Overview | |
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| Cell Proliferation Machinery | |
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| Machinery for Programmed Cell Death | |
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| Controlling the Cell-Proliferation and Death Machinery | |
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| Cancer: The Genetics of Aberrant Cell Control | |
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| Cancer Research in the Genomic Analysis Era | |
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| Developmental Genetics | |
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| Central Themes of Developmental Genetics | |
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| Gene Regulation at Levels Other Than Transcription Initiation: Examples | |
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| Binary Fate Decisions: Pathways of Sex Determination | |
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| Drosophila Sex Determination: Every Cell for Itself | |
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| Sex Determination in Mammals: Coordinated Control by the Endocrine System | |
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| Binary Fate Decisions: The Germ Line versus the Soma | |
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| Forming Complex Pattern: Establishing Positional Information | |
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| Forming Complex Pattern: Utilizing Positional Information to Establish Cell Fates | |
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| Additional Aspects of Pattern Formation | |
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| The Many Parallels in Vertebrate and Insect Pattern Formation | |
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| Do the Lessons of Animal Development Apply to Plants? | |
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| Genes at the Population Level | |
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| Population Genetics | |
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| Variation and Its Modulation | |
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| Effect of Sexual Reproduction on Variation | |
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| Sources of Variation | |
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| Selection | |
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| Balanced Polymorphism | |
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| Artificial Selection | |
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| Random Events | |
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| Quantitative Genetics | |
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| Some Basic Statistical Notions | |
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| Genotypes and Phenotypic Distribution | |
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| Norm of Reaction and Phenotypic Distribution | |
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| Determining Norms of Reaction | |
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| Heritability of a Trait | |
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| Quantifying Heritability | |
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| Locating the Genes | |
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| More on Analyzing Variance | |
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| Evolutionary Genetics | |
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| A Synthesis of Forces: Variation and Divergence of Populations | |
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| Multiple Adaptive Peaks | |
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| Heritability of Variation | |
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| Observed Variation Within and Between Populations | |
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| Process of Speciation | |
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| Origin of New Genes | |
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| Rate of Molecular Evolution | |
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| Genetic Nomenclature | |
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| Further Readings | |
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| Glossary | |
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| Answers to Selected Problems | |
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| Index | |