| Foreword | p. vii |
| Preface | p. ix |
| Preface to the Second Edition | p. xi |
| Preface to the First Edition | p. xii |
| Acknowledgments | p. xiii |
| Contributors | p. xv |
| Art and Science of Medicine | |
| Role of the Primary Care Physician | p. 2 |
| Physician and the Medical Environment | p. 4 |
| Bedside Techniques | p. 6 |
| Diagnostic Studies | p. 8 |
| Prevention and Screening | p. 11 |
| Alternative Medicine | p. 16 |
| Medical Ethics | p. 17 |
| Questions and Answers | p. 23 |
| Allergy and Clinical Immunology | |
| Basic Mechanisms | p. 28 |
| Rhinitis, Sinusitis, and Conjunctivitis | p. 34 |
| Bronchial Asthma | p. 42 |
| Anaphylaxis | p. 53 |
| Drug Allergy | p. 56 |
| Urticaria and Angioedema | p. 60 |
| Immunodeficiency | p. 64 |
| Questions and Answers | p. 67 |
| Behavioral Medicine | |
| A Biopsychosocial Approach to Patient Care | p. 72 |
| Somatic Distress Disorders | p. 74 |
| Anxiety Disorders | p. 76 |
| Depressive Disorders | p. 81 |
| Psychotic Disorders | p. 85 |
| Eating Disorders | p. 91 |
| Substance Abuse | p. 94 |
| Clinical Toxicology | p. 102 |
| Questions and Answers | p. 108 |
| Cardiovascular Diseases | |
| Common Presentations of Heart Disease in Adults | p. 112 |
| Cardiovascular Examination | p. 114 |
| Electrocardiography | p. 124 |
| Noninvasive Cardiac Imaging | p. 130 |
| Cardiac Catheterization | p. 134 |
| Disorders of Cardiac Rhythm and Conduction | p. 136 |
| Syncope | p. 161 |
| Congestive Heart Failure | p. 166 |
| Coronary Artery Disease | p. 179 |
| Acute Myocardial Infarction | p. 189 |
| Congenital Heart Diseases | p. 200 |
| Valvular Heart Disease | p. 208 |
| Pericardial Diseases | p. 218 |
| Infective Endocarditis | p. 223 |
| Diseases of the Myocardium | p. 228 |
| Diseases of the Aorta | p. 234 |
| Peripheral Vascular Disease | p. 239 |
| Cardiogenic Shock | p. 241 |
| Assessment of Cardiac Risk for Noncardiac Surgery | p. 245 |
| Questions and Answers | p. 248 |
| Dermatologic Disorders | |
| General Approach to Dermatologic Disorders | p. 256 |
| Principles of Topical Treatment | p. 259 |
| Papulosquamous Disorders | p. 262 |
| Vesicobullous Disorders | p. 265 |
| Hypersensitivity Disorders | p. 269 |
| Dermatitis-Eczema | p. 272 |
| Benign Tumors of the Skin | p. 276 |
| Malignant Tumors of the Skin | p. 279 |
| Acne | p. 283 |
| Fungal Infections of the Skin | p. 286 |
| Bacterial Infections of the Skin | p. 291 |
| Viral Infections of the Skin | p. 295 |
| Infestations of the Skin | p. 299 |
| Pigmentary Disorders of the Skin | p. 301 |
| Questions and Answers | p. 302 |
| Endocrine and Metabolic Disorders | |
| Diseases of the Anterior Pituitary Gland | p. 306 |
| Disorders of the Posterior Pituitary Gland | p. 314 |
| Thyroid Diseases | p. 319 |
| Diseases of the Parathyroid Glands, Vitamin D Metabolism, and Calcium Homeostasis | p. 329 |
| Metabolic Bone Disease | p. 337 |
| Diseases of the Adrenal Cortex | p. 341 |
| Diseases of the Adrenal Medulla | p. 348 |
| Disorders of Ovarian Function | p. 351 |
| Disorders of Testicular Function | p. 360 |
| Hypoglycemia and Diabetes Mellitus | p. 364 |
| Nutritional Disorders | p. 375 |
| Disorders of Lipid Metabolism | p. 383 |
| Questions and Answers | p. 387 |
| Gastroenterology and Diseases of the Liver | |
| Gastroenterology | |
| General Approach to the Patient with Gastrointestinal Diseases | p. 395 |
| Diarrhea | p. 400 |
| Malabsorption | p. 405 |
| Gastrointestinal Hemorrhage | p. 410 |
| Nonmalignant Diseases of the Esophagus | p. 411 |
| Carcinoma of the Esophagus | p. 418 |
| Gastric Physiology and Tests of Gastric Function | p. 419 |
| Gastritis and Other Disorders | p. 420 |
| Peptic Ulcer Disease | p. 422 |
| Neoplasms of the Stomach | p. 427 |
| Anatomy and Physiology of the Small Intestine | p. 428 |
| Infectious Enteritis | p. 430 |
| Selected Small Bowel Diseases Causing Malabsorption | p. 433 |
| Mesenteric Vascular Disease and Insufficiency | p. 437 |
| Neoplasms of the Small Intestine | p. 438 |
| Intestinal Obstruction and Paralytic Ileus | p. 439 |
| Regional Enteritis | p. 440 |
| Physiology of the Colon | p. 442 |
| Procedures in the Diagnosis of Colonic Disorders | p. 443 |
| Motility Disorders of the Colon | p. 444 |
| Inflammatory Bowel Disease | p. 446 |
| Diverticular Disease of the Colon | p. 450 |
| Appendicitis | p. 452 |
| Acute Infectious Colitis | p. 452 |
| Other Colorectal Disorders | p. 453 |
| Colorectal Neoplasms | p. 455 |
| Anatomy and Physiology of the Pancreas | p. 458 |
| Pancreatitis | p. 459 |
| Cystic Fibrosis | p. 465 |
| Neoplasms of the Pancreas | p. 466 |
| Questions and Answers | p. 467 |
| Diseases of the Liver | |
| Anatomy and Physiology of the Liver and Laboratory Evaluation of Liver Function | p. 470 |
| Clinical Presentations of Liver Disease | p. 474 |
| Viral Hepatitis | p. 476 |
| Autoimmune and Chronic Hepatitis | p. 481 |
| Alcoholic and Drug-induced Liver Disease | p. 482 |
| Cirrhosis | p. 484 |
| Metabolic Liver Diseases | p. 489 |
| Other Liver Diseases | p. 491 |
| Tumors of the Liver | p. 493 |
| The Gallbladder and Biliary Tract | p. 495 |
| Diseases of the Gallbladder and Biliary Tract | p. 496 |
| Gallstones | p. 498 |
| Chronic Cholestatic Liver Disease | p. 501 |
| Cystic Diseases of the Liver and Biliary Tree | p. 502 |
| Neoplasms of the Biliary Tree | p. 503 |
| Questions and Answers | p. 503 |
| Geriatric Medicine | |
| Aging Process | p. 508 |
| Clinical Approach to the Elderly Patient | p. 508 |
| Age-related Changes in Organ Systems | p. 512 |
| Delirium and Dementia | p. 516 |
| Urinary Incontinence | p. 519 |
| Disturbances of Temperature Regulation | p. 521 |
| Miscellaneous Syndromes with Increased Prevalence in the Elderly | p. 522 |
| Questions and Answers | p. 525 |
| Hematologic Disorders | |
| Proliferation and Differentiation of Circulating Blood Cells | p. 528 |
| General Aspects of Anemia | p. 529 |
| Hypochromic, Microcytic Anemias | p. 534 |
| The Macrocytic Anemias | p. 540 |
| Aplastic Anemias | p. 543 |
| General Aspects of Hemolytic Anemias | p. 544 |
| Hemolytic Anemias Due to Intracorpuscular Defects | p. 546 |
| Hemolytic Anemias Due to Extracorpuscular Defects | p. 553 |
| Disorders of Phagocytic Cells | p. 555 |
| Evaluation of the Patient with a Bleeding Disorder | p. 560 |
| Bleeding Disorders Due to Factor Deficiencies | p. 565 |
| Bleeding Associated with Platelet Disorders | p. 567 |
| Acquired Bleeding Disorders | p. 570 |
| Thrombotic Disorders | p. 574 |
| Erythrocytosis | p. 576 |
| Chronic Myelocytic Leukemia and Myelofibrosis | p. 579 |
| Essential Thrombocythemia | p. 581 |
| The Myelodysplastic Syndromes | p. 582 |
| Chronic Lymphocytic Leukemia (CLL) | p. 583 |
| Acute Leukemia | p. 584 |
| Clinical Uses of Blood and Blood Components | p. 588 |
| Questions and Answers | p. 592 |
| Infectious Diseases | |
| Host Defenses | p. 596 |
| Manifestations of Infection | p. 601 |
| Laboratory Diagnosis of Infectious Diseases | p. 603 |
| Microbes That Cause Infection | p. 607 |
| Antimicrobial Therapy and General Principles of Antibiotic Use | p. 612 |
| Fever and Fever of Unknown Origin | p. 618 |
| Upper Respiratory Tract Infections | p. 621 |
| Pneumonias | p. 624 |
| Urinary Tract Infections | p. 630 |
| Sexually Transmitted Diseases | p. 635 |
| Infectious Diarrhea | p. 640 |
| Intra-abdominal Infections | p. 641 |
| Central Nervous System Infections | p. 642 |
| Bacteremia, Sepsis, and Septic Syndrome | p. 648 |
| Nosocomial Infections | p. 652 |
| Skin, Soft Tissue, and Bone Infections | p. 653 |
| Infections in the Immunocompromised Host | p. 657 |
| Human Immunodeficiency Virus Infection and the Acquired Immune Deficiency Syndrome | p. 661 |
| Questions and Answers | p. 669 |
| Kidney Diseases, Electrolyte Disorders, and Hypertension | |
| Kidney Diseases | |
| Structure and Function of the Kidneys and Urinary Tract | p. 674 |
| Initial Evaluation of Kidney Disease | p. 676 |
| Nephrotic Syndrome | p. 680 |
| Acute Renal Failure | p. 682 |
| Chronic Renal Failure | p. 684 |
| Nephrolithiasis | p. 686 |
| Glomerular Diseases | p. 688 |
| Tubulointerstitial Nephropathy | p. 691 |
| Vascular Diseases of the Kidney | p. 693 |
| Cystic Diseases of the Kidney | p. 694 |
| Human Immunodeficiency Virus (HIV) Nephropathy | p. 695 |
| Fluid, Electrolyte, and Acid-Base Disorders | |
| Disorders of Water Balance | p. 696 |
| Disorders of Potassium Balance | p. 699 |
| Acid-Base Disorders | p. 702 |
| Hypertension | |
| Definition, Epidemiology, and Pathophysiology of Hypertension | p. 707 |
| Evaluation of the Hypertensive Patient | p. 709 |
| Clinical Pharmacology of Antihypertensive Drugs | p. 712 |
| Therapy of Essential Hypertension | p. 715 |
| Secondary Hypertension | p. 716 |
| Hypertensive Emergencies | p. 719 |
| Questions and Answers | p. 720 |
| Neurologic Disorders | |
| Approach to the Patient with a Neurologic Disorder | p. 726 |
| Coma | p. 731 |
| Headaches | p. 733 |
| Dizziness | p. 736 |
| Stroke | p. 740 |
| Seizures | p. 745 |
| Neurologic Aspects of Low Back Pain and Neck Pain | p. 747 |
| Disorders of Spinal Cord, Nerves, and Muscles | p. 748 |
| Multiple Sclerosis | p. 752 |
| Movement Disorders | p. 754 |
| Brain Death | p. 755 |
| Questions and Answers | p. 756 |
| Oncology | |
| Cancer and Carcinogenesis | p. 762 |
| Principles of Cancer Therapy | p. 765 |
| Hodgkin's Disease | p. 774 |
| Non-Hodgkin's Lymphomas | p. 778 |
| Multiple Myeloma and Plasma Cell Dyscrasias | p. 782 |
| Breast Cancer | p. 786 |
| Carcinoma of the Lung | p. 793 |
| Gastrointestinal Cancers | p. 798 |
| Cancers of the Kidney, Urinary Bladder, and Prostate | p. 801 |
| Cancer of the Testis | p. 807 |
| Gynecological Neoplasms | p. 809 |
| Selected Endocrine Gland Tumors | p. 812 |
| Cancer of the Head and Neck | p. 813 |
| Malignant Tumors of the Central Nervous System | p. 815 |
| Sarcomas | p. 817 |
| Metastatic Cancer of Unknown Primary Site | p. 818 |
| Paraneoplastic Syndromes | p. 820 |
| Oncologic Emergencies | p. 822 |
| Questions and Answers | p. 826 |
| Pulmonary Diseases | |
| Clinical Evaluation of Lung Disease | p. 831 |
| Basic Laboratory Tests | p. 836 |
| Imaging in Pulmonary Diagnosis | p. 838 |
| Basic Anatomy, Physiology, and Pulmonary Function Testing | p. 839 |
| Bronchoscopy and Biopsy Procedures | p. 843 |
| General Aspects of Endemic Mycoses | p. 844 |
| Histoplasmosis | p. 845 |
| Coccidioidomycosis | p. 847 |
| Blastomycosis | p. 849 |
| Aspergillosis | p. 850 |
| Tuberculosis | p. 853 |
| Atypical Mycobacterioses | p. 858 |
| Obstructive Disorders of the Airways | p. 859 |
| Chronic Bronchitis and Emphysema | p. 859 |
| Small Airways Disease | p. 866 |
| Cystic Fibrosis and Bronchiectasis | p. 866 |
| Bronchial Obstruction, Atelectasis, and Upper Airway Obstruction | p. 869 |
| Pulmonary Edema | p. 870 |
| Pulmonary Thromboembolism | p. 871 |
| Pulmonary Hypertension | p. 880 |
| Cor Pulmonale | p. 883 |
| Interstitial Lung Disease | p. 885 |
| Sarcoidosis | p. 888 |
| Pleuro-Pulmonary Manifestations of Collagen-Vascular Disorders and Vasculitides | p. 892 |
| Interstitial Lung Disease Associated with Bronchiolitis | p. 894 |
| Interstitial Lung Disease in Histiocytosis X | p. 896 |
| Hypersensitivity Pneumonitides | p. 896 |
| Silicosis | p. 897 |
| Asbestosis | p. 899 |
| Idiopathic Pulmonary Fibrosis | p. 900 |
| Radiation Pneumonitis and Radiation Fibrosis | p. 901 |
| Pulmonary Aspiration Syndromes | p. 902 |
| Drug-induced Pulmonary Disease | p. 906 |
| Bronchogenic Carcinoma | p. 907 |
| The Solitary Pulmonary Nodule | p. 909 |
| Pleural Effusion | p. 911 |
| Pneumothorax | p. 916 |
| Asbestos Pleural Disease, Fibrothorax, and Pleural Tumors | p. 917 |
| Disorders of the Mediastinum | p. 918 |
| Acute Respiratory Failure | p. 920 |
| Acute Ventilatory Failure in Chronic Obstructive Pulmonary Disease and Neuromuscular Diseases | p. 922 |
| Adult Respiratory Distress Syndrome | p. 924 |
| Sleep-disordered Breathing | p. 927 |
| Questions and Answers | p. 930 |
| Rheumatic Diseases | |
| Evaluation of Joint Diseases | p. 936 |
| Clinical Presentations of Rheumatic Conditions and Principles of Therapy | p. 940 |
| Crystal-induced Synovitis | p. 944 |
| Osteoarthritis | p. 949 |
| Rheumatoid Arthritis | p. 951 |
| Infectious Arthritis | p. 956 |
| Seronegative Spondyloarthropathies | p. 959 |
| Systemic Lupus Erythematosus | p. 962 |
| Other Connective Tissue Diseases | p. 965 |
| Vasculitis | p. 970 |
| Regional (Nonarticular) Musculoskeletal Pain | p. 972 |
| Questions and Answers | p. 978 |
| Index | p. 981 |
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