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Medicinal Natural Products A Biosynthetic Approach

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ISBN-10: 0471974781

ISBN-13: 9780471974789

Edition: 1st 1997

Authors: Paul M. Dewick

List price: $72.95
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Description:

An invaluable reference source, this concise and informative textbook provides a comprehensive introduction to natural products in medicine from a biosynthetic perspective.
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Book details

List price: $72.95
Edition: 1st
Copyright year: 1997
Publisher: John Wiley & Sons, Incorporated
Publication date: 10/3/1997
Binding: Paperback
Pages: 476
Size: 7.44" wide x 9.78" long x 1.04" tall
Weight: 1.980
Language: English

How to Use This Book
The Subject
The Aim
The Approach
The Topics
Be Selective
To Learn, or to Understand?
Conventions Regarding Acids, Bases, and Ions
Some Common Abbreviations
Further Reading
Secondary Metabolism: the Building Blocks and Construction Mechanisms
Primary and Secondary Metabolism
The Building Blocks
The Construction Mechanisms
Alkylation Reactions: Nucleophilic Substitution
Alkylation Reactions: Electrophilic Addition
Wagner-Meerwein Rearrangements
Aldol and Claisen Reactions
Schiff Base Formation and the Mannich Reaction
Transamination
Decarboxylation Reactions
Oxidation and Reduction Reactions
Dehydrogenases
Oxidases
Mono-oxygenases
Dioxygenases
Amine Oxidases
Baeyer-Villiger Oxidations
Phenolic Oxidative Coupling
Glycosylation Reactions
Some Vitamins Associated with the Construction Mechanisms
Vitamin B[subscript 1], Vitamin B[subscript 2], Vitamin B[subscript 5], Vitamin B[subscript 6], Vitamin B[subscript 12], Vitamin H
Further Reading
The Acetate Pathway: Fatty Acids and Polyketides
Saturated Fatty Acids
Unsaturated Fatty Acids
Evening Primrose Oil
Acetylenic Fatty Acids
Branched-Chain Fatty Acids
Prostaglandins
Prostaglandins
Thromboxanes
Thromboxanes
Leukotrienes
Leukotrienes
Aromatic Polyketides
Cyclization: Simple Phenols
Structural Modifications: Anthraquinones
Senna, Cascara, Frangula, Allied Drugs
C-Alkylation Reactions
Mycophenolic Acid, Khellin and Cromoglycate
Phenolic Oxidative Coupling
Griseofulvin
Oxidative Cleavage of Aromatic Rings
Starter Groups other than Acetate
Poison Ivy and Poison Oak, Aflatoxins, Cannabis, Tetracyclines, Anthracycline Antibiotics
Extender Groups other than Malonate: Macrolides and Polyethers
Macrolide Antibiotics, Avermectins, Polyene Antifungals, Tacrolimus and Sirolimus, Ansa Macrolides
Cyclization through Diels-Alder Reactions
Mevastatin and other Statins
Further Reading
The Shikimate Pathway: Aromatic Amino Acids and Phenylpropanoids
Aromatic Amino Acids and Simple Benzoic Acids
Folic Acid (Vitamin B[subscript 9]), Chloramphenicol
Cinnamic Acids
Lignans and Lignin
Podophyllum
Phenylpropenes
Benzoic Acids from C[subscript 6]C[subscript 3] Compounds
Coumarins
Dicoumarol and Warfarin, Psoralens
Flavonoids
Flavonolignans
Silybum marianum
Isoflavonoids
Derris and Lonchocarpus
Terpenoid Quinones
Vitamin E, Vitamin K
Further Reading
The Mevalonate Pathway: Terpenoids and Steroids
Hemiterpenes (C[subscript 5])
Monoterpenes (C[subscript 10])
Irregular Monoterpenes
Pyrethrins
Iridoids (C[subscript 10])
Valerian
Sesquiterpenes (C[subscript 15])
Feverfew, Camomile and Matricaria, Artemisia annua and Artemisinin, Gossypol, Trichothecenes
Diterpenes (C[subscript 20])
Taxus brevifolia and Taxol (Paclitaxel), Ginkgo biloba, Forskolin
Sesterterpenes (C[subscript 25])
Triterpenes (C[subscript 30])
Triterpenoid Saponins
Liquorice, Quillaia, Ginseng
Modified Triterpenoids
Tetraterpenes (C[subscript 40])
Vitamin A
Higher Terpenoids
Steroids
Stereochemistry
Cholesterol
Cholesterol
Steroidal Saponins
Dioscorea, Fenugreek, Sisal, Sarsaparilla, Yucca
Cardioactive Glycosides
Digitalis purpurea, Digitalis lanata, Strophanthus, Convallaria, Squill, Toxic Plants
Phytosterols
Soya Bean Sterols, Fusidic Acid
Vitamin D
Vitamin D
Ecdysones and Brassinosteroids
Bile Acids
Bile Acids
Adrenocortical Hormones/Corticosteroids
Semi-synthesis of Corticosteroids
Corticosteroid Drugs
Progestogens
Progestogen Drugs
Oestrogens
Oestrogen Drugs, Aromatase Inhibitors
Androgens
Androgen Drugs
Further Reading
Alkaloids
Alkaloids Derived from Ornithine
Pyrrolidine and Tropane Alkaloids
Belladonna, Stramonium, Hyoscyamus, Duboisia, Allied Drugs, Hyoscyamine, Hyoscine, and Atropine, Coca
Pyrrolizidine Alkaloids
Alkaloids Derived from Lysine
Piperidine Alkaloids
Lobelia
Quinolizidine Alkaloids
Indolizidine Alkaloids
Alkaloids Derived from Nicotinic Acid
Pyridine Alkaloids
Vitamin B[subscript 3], Tobacco, Areca
Alkaloids Derived from Tyrosine
Phenylethylamines and Simple Tetrahydroisoquinoline Alkaloids
Catecholamines, Lophophora, Curare
Modified Benzyltetrahydroisoquinoline Alkaloids
Opium
Phenethylisoquinoline Alkaloids
Colchicum
Terpenoid Tetrahydroisoquinoline Alkaloids
Ipecacuanha
Alkaloids Derived from Tryptophan
Simple Indole Alkaloids
Psilocybe
Simple [beta]-Carboline Alkaloids
Terpenoid Indole Alkaloids
Rauwolfia, Catharanthus, Nux-vomica, Ellipticine
Quinoline Alkaloids
Cinchona, Camptothecin
Pyrroloindole Alkaloids
Physostigma
Ergot Alkaloids
Ergot, Morning Glories
Alkaloids Derived from Anthranilic Acid
Quinazoline Alkaloids
Quinoline and Acridine Alkaloids
Alkaloids Derived from Histidine
Imidazole Alkaloids
Pilocarpus
Alkaloids Derived by Amination Reactions
Acetate-derived Alkaloids
Conium maculatum
Phenylalanine-derived Alkaloids
Ephedra, Khat
Terpenoid Alkaloids
Aconite
Steroidal Alkaloids
Solanum alkaloids
Purine Alkaloids
Caffeine, Theobromine, and Theophylline, Coffee, Tea, Cola, Cocoa, Mate tea, Guarana
Saxitoxin and Tetrodotoxin
Saxitoxin, Tetrodotoxin
Further Reading
Peptides, Proteins, and Other Amino Acid Derivatives
Peptides and Proteins
Ribosomal Peptide Biosynthesis
Peptide Hormones
Thyroid Hormones
Thyroxine, Calcitonin
Hypothalamic Hormones
Thyrotrophin-releasing Hormone, Luteinizing-hormone-releasing Hormone, Growth-hormone-releasing Hormone/Factor, Somatostatin
Anterior Pituitary Hormones
Corticotrophin, Growth Hormone, Gonadotrophins
Posterior Pituitary Hormones
Oxytocin, Vasopressin
Pancreatic Hormones
Insulin, Glucagon
Interferons
Interferons
Opioid Peptides
Enzymes
Multi-enzyme Peptide Biosynthesis
Peptide Antibiotics
Cycloserine, Polymyxins, Bacitracins, Tyrothricin and gramicidins, Capreomycin, Vancomycin and Teicoplanin, Bleomycin, Cyclosporins, Dactinomycin
Peptide Toxins
Death Cap (Amanita phalloides), Ricin, Botulinum toxin, Microcystins, Snake Venoms
Modified Peptides: Penicillins, Cephalosporins and Other [beta]-Lactams
Penicillins
Penicillins
Cephalosporins
Cephalosporins, Cephamycins
Other [beta]-Lactams
Clavulanic Acid, Carbapenems, Monobactams
Cyanogenic Glycosides
Glucosinolates
Cysteine Sulphoxides
Garlic
Further Reading
Carbohydrates
Monosaccharides
Oligosaccharides
Monosaccharides and Disaccharides
Polysaccharides
Polysaccharides
Amino Sugars
Aminoglycosides
Aminoglycoside Antibiotics, Streptamine-containing Antibiotics, 2-Deoxystreptamine-containing Antibiotics, Lincomycin and Clindamycin
Further Reading
Index